N-Nitroso Desmethyl Citalopram NEW

N-Nitroso Desmethyl Citalopram

Product Information

• Product Number: N031095

• English Name: N-Nitroso Desmethyl Citalopram

• English Alias: N-(3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)-N-methylnitrous amide

• CAS Number: None

• Molecular Formula: C₁₉H₁₈FN₃O₂

• Molecular Weight: 339.36

Advantages

• Well-defined with distinct functional groups: Contains isobenzofuran ring, 5-cyano, 1-(4-fluorophenyl), and 3-(N-methylnitrous amide)propyl. Unlike desmethyl citalopram, its nitrosoamide (-N-NO) polarity, fluorine electronegativity, and polycyclic hydrophobicity create significant differences, enabling precise differentiation via HPLC/ion-pair chromatography as a specific marker;

• High stability and traceability: Rigid isobenzofuran structure and stability of cyano/nitrosoamide ensure stability under dark, low-temperature conditions. As a derivative from amine nitrosation during storage/synthesis, it directly reflects amino stability and nitrite exposure, improving impurity tracing accuracy;

• High detection sensitivity: Polycyclic conjugation shows strong UV absorption (230-270nm), combined with m/z 340 [M+H]⁺ enabling ppb-level analysis via LC-MS, compatible with SSRI nitroso impurity systems.

Applications

• Pharmaceutical quality control: Used as an impurity reference standard to quantify N-Nitroso Desmethyl Citalopram in APIs, ensuring compliance with genotoxic impurity limits in pharmaceutical standards;

• Stability studies: Monitoring impurity levels under varying conditions (pH, light) to assess degradation trends and support shelf-life assurance;

• Synthesis assessment: Evaluating purity of demethylated intermediates in citalopram synthesis to reduce nitrosation risk at the source.

Background Description

Research Status

• Analytical method validation: Developing UPLC-MS/MS methods with C18 columns for separation, achieving 0.01 ppb detection limits;

• Nitrosation mechanism: Studying impurity formation kinetics under varying nitrite concentration and pH to clarify N-methylamino-to-nitrosoamide conversion pathways;

• Control strategies: Exploring nitrosation inhibitors (e.g., ascorbic acid) to keep impurity levels below safety limits (<0.001%);

• Toxicity evaluation: Conducting in vitro genotoxicity tests (e.g., Ames test) to assess potential hazards and support limit setting.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

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