N-Nitroso Desmethyl Diltiazem NEW

N-Nitroso Desmethyl Diltiazem

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E-mail: anna@molcoo.com

• English Version

• Product Information:
  Product Code: N031079
  English Name: N-Nitroso Desmethyl Diltiazem
  English Alias: (2S,3S)-2-(4-methoxyphenyl)-5-(2-(methyl(nitroso)amino)ethyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  CAS No.: 3036581-85-5
  Molecular Formula: C21H23N3O5S
  Molecular Weight: 429.49
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• Product Advantages:
  This product has high purity, which can accurately meet the strict requirements for nitroso impurity reference substances in diltiazem drug quality control and related research. It has good chemical stability and can maintain stable physical and chemical properties for a long time under standardized storage conditions, providing a strong guarantee for the repeatability and accuracy of experiments. Strict quality control is implemented during the production process, with small differences between batches, which can effectively reduce experimental errors and provide a reliable material basis for scientific research and production work.
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• Product Applications:
  It is mainly used in the quality control field of diltiazem, serving as a nitroso impurity reference substance to detect the content of this impurity in diltiazem raw materials and various preparations, ensuring that the drug quality meets relevant standards. Moreover, in the drug research and development process, it can be used to explore the formation mechanism, potential toxicity and impact on drug safety of this nitroso impurity, providing important data references for optimizing production processes and reducing impurity risks.
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• Background Description:
  Diltiazem is a commonly used calcium channel blocker, mainly used in the treatment of cardiovascular diseases such as hypertension, angina pectoris and arrhythmia. It works by inhibiting calcium ion influx to dilate blood vessels and reduce myocardial oxygen consumption. During its metabolism or storage, impurities such as N-Nitroso Desmethyl Diltiazem may be generated due to nitrosation of methylamine groups. Nitroso compounds, due to their potential carcinogenicity, have become key targets in drug quality control. Therefore, accurate detection and strict control of this impurity are of great significance for ensuring medication safety.
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• Research Status:
  At present, research on N-Nitroso Desmethyl Diltiazem mainly focuses on the development of high-sensitivity detection methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high-performance liquid chromatography-ultraviolet detection (HPLC-UV), to meet the detection requirements of trace impurities. At the same time, studies on the formation pathway, stability and toxicity evaluation of this impurity are also gradually deepening, providing a scientific basis for improving the quality standards and safety evaluation system of diltiazem.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com