NAB-14 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: NAB-14 | CAS No.: 1237541-73-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | NAB-14 |
| Description | NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compound exhibits a remarkable selectivity of more than 800-fold towards recombinant GluN2C and GluN2D when compared to GluN2A and GluN2B. Furthermore, NAB-14 possesses the ability to penetrate the blood-brain-barrier effectively [1]. |
| In vitro | NAB-14 (compound 14) demonstrates inhibitory effects, with IC50 values of 15 μM and 5.1 μM for GluN1/2AC1/2CC2 receptors, respectively [1]. At a concentration of 20 μM for 24 hours, it selectively inhibits GluN2D-containing receptors in brain slices, while not affecting GluN2A- or GluN2B-containing NMDARs in cultured cortical neurons [1]. Furthermore, a 10 μM concentration of NAB-14 decreases the peak amplitude of evoked excitatory postsynaptic currents (EPSCs) to 55 ± 3.0% and significantly lowers the τW of EPSC deactivation [1]. Additionally, at the same concentration, it reduces the peak amplitude and charge transfer of interneuron EPSCs to 59 ± 9.9% and 63 ± 9.7%, respectively, and decreases τW for interneuron EPSCs from 150 ± 12 ms to 101 ± 14 ms [1]. |
| In vivo | NAB-14 (20 mg/kg; p.o.) exhibits notable systemic exposure, reaching peak brain concentrations of 3.2 nM in mice and 3.8 nM in rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Mephenesin | Decanoic Acid | L-Glutamic acid | L-Phenylalanine | glycine | Evans blue | L-Glutamic acid monosodium salt | D-Cycloserine | D-Serine | Linalool | Memantine | Corticosterone |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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