Product Details
| Product Name:
NAT |
CAS No.:
831243-31-3 |
| Purity:
99.65% |
Supply Ability:
10g |
| Release date:
2025/10/24 |
Product Introduction
Bioactivity
| Name | NAT |
| Description | NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels and induces subsequent metabolic and transcriptional reprogramming. It exhibits neuroprotective effects in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model and may be employed in studies of neurodegenerative diseases or conditions associated with reduced NAD levels. |
| In vitro | NAT (10 µM) activates NAMPT (EC50=5.7 µM) and protects U2OS cells from the toxic effects of FK866. [1] |
| In vivo | In a chemotherapy-induced peripheral neuropathy (CIPN) mouse model, NAT (30 mg/kg, intraperitoneal injection, once daily for 2 weeks) exerted neuroprotective effects by elevating the mechanical hyperalgesia threshold. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : ≥ 80 mg/mL, Sonication is recommended.
|
| Inhibitors Related | GNE-617 | Nampt-IN-5 | LB-60-OF61 | Nampt activator-2 | OT-82 | SBI-797812 | Nampt-IN-1 | KPT9274 | CHS-828 | Nampt activator-1 | (E)-Daporinad | STF-118804 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$218.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
United States