PROTAC EZH2 Degrader-1 NEW
| Price | $215 | $645 | $975 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-30 |
Product Details
| Product Name: PROTAC EZH2 Degrader-1 | CAS No.: 2641601-67-2 |
| Supply Ability: 10g | Release date: 2025/09/30 |
Product Introduction
Bioactivity
| Name | PROTAC EZH2 Degrader-1 |
| Description | PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC molecule that effectively suppresses EZH2 methyltransferase activity, with a half-maximal IC50 of 2.7 nM. EZH2 is a histone methyltransferase crucial to tumorigenesis and cancer progression, and PROTAC EZH2 Degrader-1 represents an important chemical tool for probing its therapeutic relevance. |
| In vitro | Methods: H128 cells were pretreated with PROTAC EZH2 Degrader-1 (2 nM), followed by treatment with carboplatin, etoposide, and teniposide for 72 hours. Cell viability was assessed using the CCK8 assay. Results: PROTAC EZH2 Degrader-1 significantly reduced the IC50 values of carboplatin, etoposide, and teniposide in H128-LM cells.[2] |
| In vivo | Methods: PROTAC EZH2 Degrader-1 (0.5 mg/kg, once weekly for a total of 3 doses) was administered intraperitoneally to H128-LM xenograft mice to evaluate tumor growth. Results: The combination of PROTAC EZH2 degrader-1 with carboplatin, etoposide, and teniposide significantly inhibited the growth of H128-LM tumors, demonstrating superior efficacy compared to chemotherapy drugs used alone.[2] |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (84.91 mM), Sonication is recommended. |
| Inhibitors Related | MAK-683 hydrochloride | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | MAK683 | ARV-471 | EPZ015666 | dBET6 | iso-Azalansta | MS37452 | MRTX-1719 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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