(S)-Gossypol acetic acid NEW
| Price | $33 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-03 |
Product Details
| Product Name: (S)-Gossypol acetic acid | CAS No.: 1189561-66-7 |
| Purity: 98.69% | Supply Ability: 10g |
| Release date: 2025/11/03 |
Product Introduction
Bioactivity
| Name | (S)-Gossypol acetic acid |
| Description | (S)-Gossypol acetic acid ((S)-(+)-Gossypol acetic acid) is a conformational isomer of Gossypol that acts as a BH3 mimic capable of binding Bcl-xL and Bcl-2 proteins, with the potential to induce apoptosis and inhibit cell growth. |
| In vitro | (S)-Gossypol acetic acid inhibits proliferation and induces apoptosis in human nasopharyngeal carcinoma CNE-2 cells in a dose-dependent manner (2.5-20 μM, 24 h). (S)-Gossypol acetic acid decreases mitochondrial membrane potential, upregulates Bax, downregulates Bcl-2, and activates caspase-3[1]. |
| In vivo | In BALB/c nude mice bearing CNE-2 xenograft tumors, intraperitoneal administration of (S)-Gossypol acetic acid at 20 mg/kg/day for 21 days significantly inhibited tumor growth (~60% reduction in volume) without notable weight loss or systemic toxicity[1]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (69.13 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble) |
| Keywords | Gossypol acetic acid | Gossypol | Bcl-2 | acetic acid | (S)-Gossypol acetic acid | (S)Gossypol (acetic acid) | (S) Gossypol (acetic acid) |
| Inhibitors Related | Gossypol (acetic acid) | (S)-(+)-Ibuprofen | Allethrin | Rasagiline | Navitoclax | Diphenyl disulfide | Gossypol | Lisaftoclax | UMI-77 | Venetoclax | Sonrotoclax TFA | Thymoquinone |
| Related Compound Libraries | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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