S1R agonist 1 hydrochloride NEW
| Price | $48 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: S1R agonist 1 hydrochloride | CAS No.: 242487-82-7 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | S1R agonist 1 hydrochloride |
| Description | S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
| In vitro | S1R agonist 1 (Compound 6b; 0.1-5 μM) hydrochloride significantly enhances neurite outgrowth induced by nerve growth factor (NGF) in a dose-dependent manner in PC12 cells and, at 1 μM for 24 hours, inhibits Rotenone-induced damage in SHSY5Y cells [1]. Additionally, it demonstrates neuroprotective effects against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours and shows no cytotoxicity in A549, LoVo, and Panc-1 cells at 0-10 μM over 24-72 hours [1]. |
| In vivo | Compound 6b, a selective S1R agonist at concentrations ranging from 0.1 to 50 μM, was administered over 120 hours, resulting in the death of 4 out of 8 zebrafish embryos at a 10 μM concentration [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Sigmareceptor | Sigma receptor |
| Inhibitors Related | KB-5492 free base | Cutamesine dihydrochloride | Blarcamesine hydrochloride | Opipramol | Amitriptyline hydrochloride | S1R agonist 2 | Ditolylguanidine | 4-PPBP maleate | Sigma-1 receptor antagonist 1 | Glycerol phenylbutyrate | KSK67 | AB21 HCl |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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