SC75741 NEW
| Price | $36 | $71 | $113 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-08-30 |
Product Details
| Product Name: SC75741 | CAS No.: 913822-46-5 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2026/08/30 |
Product Introduction
Bioactivity
| Name | SC75741 |
| Description | SC75741 is a selective NF-κB inhibitor that blocks viral replication by impairing p65 DNA binding, leading to reduced cytokine and chemokine expression and inhibition of caspase-mediated nuclear export of viral ribonucleoproteins. It demonstrates potent antiviral activity against influenza A (H5N1, H7N7), bandaviruses (SFTSV, HRTV), duck Tembusu virus, and duck plague virus, with an IC₅₀ in the low micromolar range. In murine models, intravenous administration at 5 mg/kg/day or intraperitoneal doses of 15 mg/kg/day provides significant protection against lethal viral challenge. Researchers utilize SC75741 to study host-directed antiviral strategies, NF-κB/miR-21 signaling in osteoarthritis, and STING-dependent innate immune activation. |
| Cell Research | Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference) |
| Kinase Assay | NF-κB reporter gene assay: The NF-κB reporter gene assay is prepared with A549-NF-κB-SEAP cell line according to manufacturer's instructions. In short, A549 cells stably transfected with pNF-κB-SEAP reporter gene plasmid are plated and allowed to attach overnight. The cells are subsequently incubated for 5 h with described compounds at 100, 30, 10, 3, 1, 0.3, 0.1, and 0 μM and then stimulated with 10 ng/ml TNF-α for 22 h. The supernatant of the cell is analyzed for SEAP activity using a chemiluminescent SEAP reporter gene assay. |
| In vitro | SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. [1] SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants. [2] |
| In vivo | SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn oil : 10 mg/mL (17.68 mM), Solution. 10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (17.68 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (17.68 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 50 mg/mL (88.39 mM), Sonication is recommended. 10% DMSO+90% Saline : < 10 mg/mL (17.68 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | SC-75741 | SC75741 | SC 75741 | P65 | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus |
| Inhibitors Related | Chitin | Chloroxylenol | Sodium propionate | Kojic acid | Triphenyl phosphate | Curcumin | Ethyl linoleate | D-Psicose | 5-Aminosalicylic Acid | Zinc chloride | N,N-Dimethylacetamide | β-Cyclodextrin |
| Related Compound Libraries | Bioactive Compounds Library Max | Antidepressant Compound Library | Anti-Breast Cancer Compound Library | Hematonosis Compound Library | Bioactive Compound Library | Anti-Viral Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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