Splitomicin NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2026-01-04 |
Product Details
| Product Name: Splitomicin | CAS No.: 5690-03-9 |
| Purity: 98.64% | Supply Ability: 10g |
| Release date: 2026/01/04 |
Product Introduction
Bioactivity
| Name | Splitomicin |
| Description | Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
| In vitro | Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. [1] Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release. [2] |
| In vivo | In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 19.8 mg/mL (99.89 mM), Sonication is recommended. Ethanol : 19.8 mg/mL (99.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (10.09 mM), Sonication is recommended. |
| Keywords | Splitomycin | Splitomicin | SIRT2p | Inhibitor | inhibit | Histone deacetylases | HDAC |
| Inhibitors Related | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Methoxyacetic acid | Sodium 4-phenylbutyrate | Manganese chloride (tetrahydrate) | Curcumin | Valproic Acid | Sodium butanoate | Theophylline | 4-Phenylbutyric acid | Nicotinamide |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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