Stachydrine NEW
| Price | $31 | $48 | $75 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-11 |
Product Details
| Product Name: Stachydrine | CAS No.: 471-87-4 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2025/07/11 |
Product Introduction
Bioactivity
| Name | Stachydrine |
| Description | Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits. |
| Cell Research | Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot. |
| In vitro | Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05). |
| Storage | keep away from direct sunlight,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 26 mg/mL (181.59 mM), Sonication is recommended. H2O : 32 mg/mL (223.49 mM), Sonication is recommended. |
| Keywords | Stachydrine | p65 | NF-κB | NFκB | NF-kB | NFkB | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oxalic acid |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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