Synephrine Hydrochloride NEW

Factory Provide CAS 5985-28-4 Synephrine HCl Powder Synephrine Hydrochloride

Introduction

Product Name :  Synephrine Hydrochloride

Other name:1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride;4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride;Synephrine hcl

CAS No.: 5985-28-4

MF:C9H14ClNO2

MW:208.12

Specification:99%

Appearance: White to off white powder 

Melting Point :147-150°CPredicted)

Storage :Keep in dark place,Inert atmosphere,Room temperature

Synephrine Hydrochloride is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). Synephrine Hydrochloride is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). Synephrine Hydrochloride induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (ynephrine Hydrochloride (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Function 

1. Anti-oxidant, Reduce environmental pollution damage to the body;
2. Synephrine HCL can consolidate connective tissue; strengthen skin, bones, teeth and muscles;
3. Synephrine HCL can promote collagen synthesis, help wound healing;
4. Involved in cholesterol metabolism and help break down fat;
5. Synephrine HCL can accelerate iron and calcium absorption, prevent scurvy.