Thalidomide-O-amido-C4-NH2 NEW
| Price | Get Latest Price |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Thalidomide-O-amido-C4-NH2 | CAS No.: 1799711-24-2 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Thalidomide-O-amido-C4-NH2 |
| Description | Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized compound combining a Thalidomide-based cereblon ligand with a linker, serving as an E3 ligase ligand-linker conjugate for the synthesis of PROTACs[1]. |
| In vitro | Thalidomide-O-amido-C4-NH2, also known as Compound 41, serves as an amine intermediate in the synthesis of heterobifunctional PROTAC BET degraders. These degraders target the bromodomain and extra-terminal (BET) family of proteins—BRD2, BRD3, BRD4, and BRDT—which are crucial in gene transcription regulation and are attractive therapeutic targets for cancer and other diseases. Utilizing the proteolysis targeting chimera (PROTAC) approach, these small molecules induce the degradation of BET proteins. Specifically, Thalidomide-O-amido-C4-NH2 functions as a degron-linker (Compound DL6-TL), a structure that covalently links a degron to a targeting ligand. The degron binds to an E3 ubiquitin ligase (e.g., cereblon), facilitating the targeted degradation of the protein(s) bound by the targeting ligand. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Thalidomide-O-amido-C4-NH2 | Thalidomide-O-amido-C-4-NH2 | ThalidomideOamidoC4NH2 | Thalidomide O amido C4 NH2 | Cereblon |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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