E3 Ligase Ligand-Linker Conjugates 19 manufacturers
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| | E3 Ligase Ligand-Linker Conjugates 19 Basic information |
| Product Name: | E3 Ligase Ligand-Linker Conjugates 19 | | Synonyms: | E3 Ligase Ligand-Linker Conjugates 19;E3 Ligand-Linker Conjugate 3;Cereblon Ligand-Linker Conjugates 6;Thalidomide-O-amido-C4-NH2;Acetamide, N-(4-aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide;E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19);N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]oxy]acetamide | | CAS: | 1799711-24-2 | | MF: | C19H22N4O6 | | MW: | 402.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1799711-24-2.mol |  |
| | E3 Ligase Ligand-Linker Conjugates 19 Chemical Properties |
| Boiling point | 757.5±60.0 °C(Predicted) | | density | 1.397±0.06 g/cm3(Predicted) | | solubility | DMF: insol; DMSO: insol; Ethanol: insol; PBS (pH 7.2): 3 mg/ml | | form | A solid | | pka | 10.68±0.40(Predicted) |
| | E3 Ligase Ligand-Linker Conjugates 19 Usage And Synthesis |
| Description | Thalidomide-O-acetamido-C4-amine HCl salt is comprised of a Thalidomide based cereblon ligand and a ligand-linker conjugate. This E3 ligase ligand-linker conjugate is used in PROTAC technology. | | Uses | Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. | | IC 50 | Cereblon | | References | [1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. |
| | E3 Ligase Ligand-Linker Conjugates 19 Preparation Products And Raw materials |
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