GC抗体,Rabbit Polyclonal GC Antibody
  • GC抗体,Rabbit Polyclonal GC Antibody
  • GC抗体,Rabbit Polyclonal GC Antibody
  • GC抗体,Rabbit Polyclonal GC Antibody

GC抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
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产品详情

中文名称:GC抗体英文名称:Rabbit Polyclonal GC Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1777 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GC
2025-05-11 GC抗体 Rabbit Polyclonal GC Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1777 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesDBP; GRD3; VDBG; VDBP; DBP/GC
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GC
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal liver tissue, A549 cells, Primary antibody: P00791(GC Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于GC抗体(抗肾小球基底膜抗体)的3篇参考文献,简要整理如下:

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1. **文献名称**: *Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IV*

**作者**: Saus, J., Wieslander, J., Langeveld, J.P., et al.

**摘要**: 该研究首次鉴定出Goodpasture综合征的靶抗原为IV型胶原蛋白的α3链(COL4A3),揭示了自身抗体与肾小球基底膜的结合机制,为理解疾病发病机制奠定了基础。

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2. **文献名称**: *Anti-glomerular basement membrane antibody diseases: an update on subgroups, pathogenesis and therapies*

**作者**: Salama, A.D., Levy, J.B.

**摘要**: 综述文章系统总结了抗GBM抗体疾病的临床亚型、病理机制及治疗进展,强调抗体介导的肾肺损伤过程,并讨论了血浆置换与免疫抑制治疗的疗效。

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3. **文献名称**: *Clinical significance of anti-GBM antibody detection: a multicenter study*

**作者**: Sinico, R.A., Radice, A., Corace, C., et al.

**摘要**: 多中心研究评估了酶联免疫吸附法(ELISA)检测抗GBM抗体的敏感性和特异性,提出其在快速诊断Goodpasture综合征及鉴别其他肾小球疾病中的关键作用。

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如需更多文献或特定领域的参考文献,请进一步说明。

       

背景信息

GC antibodies, also known as anti-glomerular basement membrane (anti-GBM) antibodies, are autoantibodies targeting type IV collagen in the basement membranes of glomeruli and alveoli. First identified in the 1960s, these antibodies are primarily associated with Goodpasture syndrome, a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis and pulmonary hemorrhage. The pathogenic antibodies bind to the non-collagenous (NC1) domain of the α3 chain of type IV collagen, triggering complement activation and inflammatory damage.

Genetic and environmental factors, such as HLA-DR15 susceptibility and hydrocarbon exposure, may contribute to disease onset. Diagnosis relies on detecting circulating anti-GBM antibodies via ELISA or immunofluorescence, alongside kidney biopsy showing linear IgG deposits. While historically fatal, advancements in immunosuppressive therapies (e.g., cyclophosphamide, corticosteroids) and plasma exchange have significantly improved survival rates.

Interestingly, low titers of anti-GBM antibodies occasionally occur without clinical disease, suggesting complex immune regulation. Research continues to explore epitope-specific antibody profiles and novel biologics for refractory cases. GC antibody-mediated diseases exemplify the interplay between autoimmunity and organ-specific pathology, emphasizing early detection and targeted intervention.

       
关键字: GC抗体;GC;GC Antibody;

公司简介

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员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
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  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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