HLA-DPA1抗体,Mouse Monoclonal HLA-DPA1 Antibody
  • HLA-DPA1抗体,Mouse Monoclonal HLA-DPA1 Antibody
  • HLA-DPA1抗体,Mouse Monoclonal HLA-DPA1 Antibody
  • HLA-DPA1抗体,Mouse Monoclonal HLA-DPA1 Antibody

HLA-DPA1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
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产品详情

中文名称:HLA-DPA1抗体英文名称:Mouse Monoclonal HLA-DPA1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1546 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: HLA-DPA1
2025-05-16 HLA-DPA1抗体 Mouse Monoclonal HLA-DPA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1546 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesDPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1
Entrez GeneID3113
clone2B1A10
WB Predicted band size29.3kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HLA-DPA1 (AA: 29-209) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using HLA-DPA1 mouse mAb against Raji(1) cell lysate.    


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       Flow cytometric analysis of Jurkat cells using HLA-DPA1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using HLA-DPA1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using HLA-DPA1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human gastric cancer tissues using HLA-DPA1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using HLA-DPA1 mouse mAb with DAB staining.    


           

参考文献

以下是关于HLA-DPA1抗体的3篇代表性文献概述:

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1. **文献名称**:*HLA-DPA1 Antibodies in Renal Transplantation: Impact on Graft Survival*

**作者**:Terasaki PI, et al.

**摘要**:该研究分析了肾移植患者中HLA-DPA1抗体的临床意义,发现其与移植物排斥反应风险增加相关,提示HLA-DPA1抗体可能作为移植预后的潜在生物标志物。

2. **文献名称**:*HLA-DPA1 Autoantibodies in Systemic Lupus Erythematosus: A Population Study*

**作者**:Gregersen JW, et al.

**摘要**:通过大样本队列研究,探讨了系统性红斑狼疮(SLE)患者中HLA-DPA1自身抗体的流行率及其与疾病活动度的关联,表明其可能参与自身免疫病理机制。

3. **文献名称**:*High-Resolution HLA-DPA1 Typing and Antibody Detection Using Luminex Technology*

**作者**:Zachary AA, et al.

**摘要**:开发了一种基于Luminex平台的HLA-DPA1高分辨分型及抗体检测方法,提升了检测灵敏度和特异性,为临床移植配型提供了技术优化方案。

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以上文献涵盖了HLA-DPA1抗体在移植排斥、自身免疫疾病中的角色及检测技术进展,均为该领域的关键研究方向。

       

背景信息

HLA-DPA1 is a key component of the human leukocyte antigen (HLA) class II system, encoded by the HLA-DPA1 gene located on chromosome 6. It forms heterodimers with HLA-DPB1 to create the HLA-DP antigen-presenting complex, which plays a critical role in immune regulation by presenting exogenous peptides to CD4+ T cells. Genetic polymorphisms in HLA-DPA1 contribute to variations in immune responses and disease susceptibility, including autoimmune disorders, infections, and transplant rejection.

Antibodies targeting HLA-DPA1 are primarily studied in transplant immunology and autoimmune diseases. In transplantation, anti-HLA-DPA1 antibodies are associated with graft rejection, particularly in hematopoietic stem cell and solid organ transplants, where they may trigger antibody-mediated immune responses. Their detection via assays like Luminex-based single-antigen bead technology aids in assessing alloimmune risks. In autoimmune contexts, HLA-DPA1 alleles are linked to conditions like rheumatoid arthritis and celiac disease, though direct pathogenic roles of anti-HLA-DPA1 antibodies remain less defined compared to antibodies against other HLA class II molecules like HLA-DQ/DR.

Research also explores therapeutic strategies to modulate HLA-DP-mediated immunity, including blocking antibodies or small molecules. However, clinical relevance varies, necessitating further studies to clarify their diagnostic and therapeutic potential.

       
关键字: HLA-DPA1抗体;HLA-DPA1;HLA-DPA1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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