**Background of NGFR Antibody**
The nerve growth factor receptor (NGFR), also known as p75 neurotrophin receptor (p75NTR), is a transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. It binds to neurotrophins, including NGF, BDNF, and NT-3. playing dual roles in regulating neuronal survival, differentiation, and apoptosis. Unlike the tropomyosin receptor kinase (Trk) family, NGFR often induces apoptotic signaling in the absence of Trk co-activation, contributing to developmental pruning of neurons and pathological conditions like neurodegeneration.
NGFR is expressed in both neural and non-neural tissues, including certain cancers, where it can promote tumor progression, invasion, and therapy resistance. Its involvement in diseases such as Alzheimer’s, Parkinson’s, and cancer has driven interest in targeting NGFR for diagnostics and therapeutics.
NGFR antibodies are critical tools for detecting and studying this receptor’s expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, therapeutic NGFR antibodies are being explored to modulate neurotrophin signaling, block pro-survival pathways in cancer, or deliver cytotoxic agents in targeted therapies. Recent research also highlights their potential in addressing nerve regeneration and pain management. As NGFR’s context-dependent roles become clearer, antibodies remain pivotal in unraveling its mechanisms and advancing clinical applications.