The POLD2 antibody is a crucial tool for studying the DNA polymerase delta subunit 2 (POLD2), a vital component of the DNA polymerase delta complex. This enzyme plays a central role in eukaryotic DNA replication and repair, particularly in synthesizing and proofreading lagging-strand DNA during replication. POLD2. as the second regulatory subunit, stabilizes the complex and modulates its enzymatic activity, ensuring genomic integrity. Researchers use POLD2 antibodies to investigate its expression, localization, and interaction with other replication/repair proteins in cellular processes like cell cycle progression, DNA damage response, and telomere maintenance. These antibodies are widely applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess POLD2 levels in cancer studies, as dysregulation of DNA replication machinery is linked to tumorigenesis and genomic instability. Commercially available POLD2 antibodies are typically validated for specificity in human, mouse, or rat samples, aiding mechanistic studies of replication errors, aging-related disorders, and targeted therapies. Understanding POLD2's role through antibody-based assays contributes to insights into diseases like cancer, developmental syndromes, and chemotherapy resistance mechanisms.