MAP1A抗体;MAP1A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11373(MAP1A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11373(MAP1A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

MAP1A (Microtubule-Associated Protein 1A) is a high-molecular-weight protein critical for microtubule stability and neuronal development. It belongs to the MAP1 family, which includes MAP1B, and plays a key role in regulating cytoskeletal dynamics by binding to microtubules and modulating their assembly. MAP1A is predominantly expressed in mature neurons, where it localizes to axons and dendrites, contributing to synaptic plasticity, intracellular transport, and maintenance of neuronal morphology. The protein is synthesized as a precursor that undergoes proteolytic cleavage to generate separate heavy and light chains, which function cooperatively.

MAP1A antibodies are essential tools in neuroscience research, widely used to investigate microtubule organization, neuronal differentiation, and synaptic connectivity. These antibodies are commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MAP1A expression patterns in brain tissues or cultured neurons. Studies using MAP1A-specific antibodies have helped elucidate its role in neurodevelopmental processes and its potential involvement in neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Some antibodies distinguish MAP1A from its homolog MAP1B, enabling isoform-specific analysis. Commercial MAP1A antibodies are typically raised against epitopes within the N-terminal or C-terminal regions, with validation in knockout models ensuring specificity. Their application has advanced understanding of how microtubule-associated proteins contribute to both normal brain function and disease pathology.