CLTC抗体;CLTC Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 cells, hela cells, Primary antibody: P11667(CLTC Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11667(CLTC Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11667(CLTC Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CLTC (Clathrin Heavy Chain) antibodies are essential tools in studying the structure and function of clathrin, a key protein involved in intracellular trafficking. Clathrin forms triskelion-shaped complexes that assemble into lattice structures, facilitating vesicle formation during endocytosis and organelle biogenesis. The heavy chain (CLTC) provides the structural backbone, while light chains regulate assembly and disassembly. CLTC antibodies are widely used to investigate clathrin-mediated processes like receptor internalization, synaptic vesicle recycling, and lysosomal sorting.

These antibodies enable researchers to detect CLTC expression through techniques like Western blotting, immunofluorescence, and immunoprecipitation. They help visualize clathrin-coated pits/vesicles and track dynamic membrane trafficking events. In disease research, CLTC antibodies contribute to understanding pathologies linked to trafficking defects, including cancer metastasis (altered growth factor internalization), neurological disorders (impaired synaptic transmission), and viral entry mechanisms (e.g., HIV, influenza). Recent studies also explore CLTC's non-canonical roles in mitosis and cytoskeletal organization. Commercial CLTC antibodies are typically validated for species cross-reactivity (human, mouse, rat) and application-specific performance, with monoclonal antibodies offering high specificity and polyclonals providing broader detection capacity. Proper controls remain crucial due to potential cross-reactivity with homologous proteins.