NDUFB7抗体;NDUFB7 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12548(NDUFB7 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The NDUFB7 antibody is a research tool designed to detect the NDUFB7 protein, a critical subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) in the electron transport chain. Complex I is essential for cellular energy production, catalyzing the transfer of electrons from NADH to ubiquinone while contributing to the proton gradient across the mitochondrial inner membrane. NDUFB7. encoded by the nuclear *NDUFB7* gene, is one of over 40 subunits that assemble to form the functional Complex I structure. This hydrophobic protein localizes to the mitochondrial matrix and plays a structural or regulatory role in Complex I stability and activity.

Antibodies targeting NDUFB7 are widely used in biomedical research to investigate mitochondrial dysfunction, which is linked to neurodegenerative disorders, metabolic diseases, and cancer. They enable protein detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, helping assess expression levels, tissue distribution, or subcellular localization. Commercial NDUFB7 antibodies are typically raised in hosts such as rabbits or mice, validated for specificity using knockout controls or siRNA knockdown. Researchers also utilize these antibodies to study mutations or dysregulation of Complex I subunits in genetic mitochondrial disorders like Leigh syndrome. Proper validation remains crucial, as cross-reactivity with other Complex I subunits or degradation products can occur due to the structural complexity of the enzyme.