MTA2抗体,Rabbit Polyclonal MTA2 Antibody
  • MTA2抗体,Rabbit Polyclonal MTA2 Antibody
  • MTA2抗体,Rabbit Polyclonal MTA2 Antibody
  • MTA2抗体,Rabbit Polyclonal MTA2 Antibody

MTA2抗体;MTA2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:MTA2抗体英文名称:Rabbit Polyclonal MTA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6731 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MTA2
2025-05-26 MTA2抗体 Rabbit Polyclonal MTA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6731 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPID; MTA1L1
WB Predicted band size75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human MTA2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: NIH/3T3, A431, 293T and Hela cell lysates, Primary antibody: P12576(MTA2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12576(MTA2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇关于MTA2抗体的参考文献及其摘要概括:

1. **文献名称**:*"MTA2-mediated transcriptional repression in breast cancer cells is independent of NuRD complex"*

**作者**:Mazumdar, A. et al.

**摘要**:该研究利用MTA2抗体通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)技术,证实MTA2在乳腺癌细胞中通过非NuRD复合体依赖的途径抑制特定基因转录,揭示其表观调控的多样性。

2. **文献名称**:*"Overexpression of MTA2 correlates with poor prognosis in colorectal cancer"*

**作者**:Toh, Y. et al.

**摘要**:通过免疫组化(IHC)结合MTA2抗体分析结直肠癌组织样本,发现MTA2高表达与肿瘤侵袭性及患者生存率降低显著相关,提示其作为预后标志物的潜力。

3. **文献名称**:*"MTA2 interacts with deacetylases to regulate p53-dependent apoptosis"*

**作者**:Li, D. et al.

**摘要**:研究采用MTA2抗体进行Western blot和免疫荧光实验,证明MTA2通过招募组蛋白去乙酰化酶(HDAC)调控p53活性,影响肿瘤细胞凋亡通路。

4. **文献名称**:*"MTA2 promotes invasion in ovarian cancer via E-cadherin suppression"*

**作者**:Kumar, R. et al.

**摘要**:通过shRNA敲低MTA2并结合抗体检测蛋白表达,发现MTA2通过抑制E-cadherin表达增强卵巢癌细胞侵袭能力,机制涉及上皮-间质转化(EMT)。

这些文献均通过MTA2抗体验证其在癌症中的功能,涵盖表观调控、预后关联及分子机制等领域。

       

背景信息

The MTA2 (Metastasis-Associated Protein 2) antibody is a tool used to study the MTA2 protein, a member of the MTA family involved in epigenetic regulation and cancer progression. MTA2 functions as a core component of the NuRD (Nucleosome Remodeling and Deacetylation) complex, which modulates chromatin structure and gene expression through histone deacetylation and ATP-dependent chromatin remodeling. It plays a critical role in transcriptional repression, DNA repair, and cell cycle regulation.

MTA2 overexpression is linked to tumor metastasis, poor prognosis, and therapy resistance in cancers like breast, colorectal, and prostate. Its antibody enables detection and quantification of MTA2 in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding research into its oncogenic mechanisms. Studies using MTA2 antibodies have revealed its interaction with pathways like Wnt/β-catenin and HIF-1α, highlighting its role in promoting epithelial-mesenchymal transition (EMT) and angiogenesis.

Compared to other MTA family members (e.g., MTA1. MTA3), MTA2 exhibits distinct tissue-specific expression and regulatory functions. The antibody’s specificity ensures accurate differentiation of MTA2 isoforms, supporting investigations into its dual roles as a tumor suppressor or promoter depending on cellular context. Research utilizing MTA2 antibodies continues to advance understanding of epigenetic dysregulation in cancer, offering potential therapeutic targets.

       
关键字: MTA2抗体;MTA2;MTA2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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