Phospho-Syk (Tyr348)抗体;Phospho-Syk (Tyr348) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-Syk (Tyr348) in 3T3 lysates using Phospho-Syk (Tyr348) antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Phospho-Syk (Tyr348) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.    

  
  

Phospho-Syk (Tyr348) antibody is a specialized tool used to detect the activated form of spleen tyrosine kinase (Syk), a non-receptor tyrosine kinase critical in intracellular signaling pathways. Syk is predominantly expressed in hematopoietic cells and plays a central role in immune receptor signaling, including B-cell receptor (BCR) and Fc receptor-mediated responses. Its activation occurs through phosphorylation at specific tyrosine residues, such as Tyr348. which is located in the interdomain B region. Phosphorylation at Tyr348 is essential for Syk’s enzymatic activity and downstream signaling, facilitating interactions with adaptor proteins and propagating signals involved in cell proliferation, differentiation, and immune regulation.

This antibody specifically recognizes Syk when phosphorylated at Tyr348. enabling researchers to study its activation status in various contexts. Dysregulated Syk activity is implicated in autoimmune diseases, allergies, and hematologic malignancies, making this antibody valuable for both basic research and clinical investigations. Applications include Western blotting, immunoprecipitation, and immunofluorescence to assess Syk activation in response to stimuli like antigen receptor engagement or cytokine signaling. It is also used to explore therapeutic targets, as Syk inhibitors are under investigation for conditions like rheumatoid arthritis and leukemia. Proper controls, such as unstimulated cells or phosphatase-treated lysates, are recommended to confirm specificity. Overall, Phospho-Syk (Tyr348) antibody is a key reagent for deciphering immune signaling mechanisms and disease pathology linked to Syk dysfunction.