Chemical Safety Data Sheet MSDS / SDS
ISOPROPYLLITHIUM
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: ISOPROPYLLITHIUM
- CBnumber: CB8259532
- CAS: 1888-75-1
- EINECS Number: 217-561-4
- Synonyms: 2-Lithiopropane;2-Propyllithium
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H411 Toxic to aquatic life with long lasting effects
H336 May cause drowsiness or dizziness
H318 Causes serious eye damage
H315 Causes skin irritation
H304 May be fatal if swallowed and enters airways
H224 Extremely flammable liquid and vapour
Substance
- Product name: ISOPROPYLLITHIUM
- Synonyms: 2-Lithiopropane;2-Propyllithium
- CAS: 1888-75-1
- EC number: 217-561-4
- MF: C3H7Li
- MW: 50.03
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary failure possible after aspiration of vomit. Call a physician immediately.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Hazardous combustion products
Carbon oxides Lithium oxides
Specific extinguishing methods
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.
Handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Avoidance of contact
Forms shock-sensitive mixtures with certain other materials. Iron and iron salts. Heavy metals phosphorous Sulfur compounds Oxygen Nickel Do not store near acids. Metals Chlorinated solvents
Storage
Further information on storage conditionsTightly closed. Keep away from heat and sources of ignition.
Storage class
4.3, Hazardous materials, which set free flammable gases upon contact with water
Recommended storage
2 - 8 °C temperature
control parameter
Hazard composition and occupational exposure limitsDoes not contain substances with occupational exposure limits.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type AX
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Tightly fitting safety goggles
Flame retardant antistatic protective clothing.
Hand protection
Remarks
required
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Particle characteristics Particle sizeNo data available
- Molecular weight50.03 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/waterNo data available
- Water solubilityNo data available
- Density0.632 g/mL (25 °C)
- Relative density0.632 g/mL at 25 °C
- Relative vapor densityNo data available
- Vapor pressureNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point-35 °C
Method: closed cup - Boiling point/boiling range35 - 36 °C
- Melting point/ rangeNo data available
- pHNo data available
- Odor ThresholdNo data available
- OdorNo data available
- ColorNo data available
- Appearanceliquid
Reactivity
Vapors may form explosive mixture with air.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
Warming.
Incompatible materials
Forms shock-sensitive mixtures with certain other materials. Iron and iron salts. Heavy metals phosphorous Sulfur compounds Oxygen Nickel Do not store near acids. Metals Chlorinated solvents
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, in- flammation and edema of the larynx, spasm, inflammation and edema of the bron- chi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Headache,
Nausea, Large doses of lithium ion have caused dizziness and prostration, and can cause kidney damage if sodium intake is limited. Dehydration, weight loss, derma- tological effects, and thyroid disturbances have been reported. Central nervous system effects that include slurred speech, blurred vision, sensory loss, ataxia, and convulsions may occur. Diarrhea, vomiting, and neuromuscular effects such as tremor, clonus, and hyperactive reflexes may occur as a result of repeated expo- sure to lithium ion.
Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Central nervous system depression, Damage to the lungs.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components pentane
Nausea, Large doses of lithium ion have caused dizziness and prostration, and can cause kidney damage if sodium intake is limited. Dehydration, weight loss, derma- tological effects, and thyroid disturbances have been reported. Central nervous system effects that include slurred speech, blurred vision, sensory loss, ataxia, and convulsions may occur. Diarrhea, vomiting, and neuromuscular effects such as tremor, clonus, and hyperactive reflexes may occur as a result of repeated expo- sure to lithium ion.
Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Central nervous system depression, Damage to the lungs.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - > 25.3 mg/l - vapor (OECD Test Guideline 403)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: cyclopentane
Dermal: No data available
LC50 Inhalation - Rat - male and female - 4 h - > 25.3 mg/l - vapor (OECD Test Guideline 403)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: cyclopentane
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Method: Mutagenicity (micronucleus test)
Species: Rat - male and female - Bone marrow
Result: negative
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Method: Mutagenicity (micronucleus test)
Species: Rat - male and female - Bone marrow
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness. - Central nervous system
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
May be fatal if swallowed and enters airways.Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
isopropyllithium
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Ecotoxicity
Components:
pentane:
Toxicity to fishLC50 (Oncorhynchus mykiss (rainbow trout)): 4.26 mg/l End point: mortality Exposure time: 96 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 203 GLP: yes
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 2.7 mg/l Exposure time: 48 h Test Type: static test Analytical monitoring: yes Remarks: (ECHA)
Toxicity to algae/aquatic plants
ErC50 (Selenastrum capricornutum (green algae)): 10.7 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes NOEC (Selenastrum capricornutum (green algae)): 7.51 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes
Ecotoxicology Assessment
Chronic aquatic toxicityToxic to aquatic life with long lasting effects.
isopropyllithium:
Toxicity to fishRemarks: No data available
Persistence and degradability
Components:
pentane:
Biodegradabilityaerobic Inoculum: activated sludge Concentration: 60 mg/l Result: Readily biodegradable. Biodegradation: 87 % Exposure time: 28 d Method: OECD Test Guideline 301F GLP: yes
Bioaccumulative potential
Components:
pentane:
BioaccumulationRemarks: No data available
Partition coefficient: noctanol/water
log Pow: 3.45 (25 °C) pH: 7 Remarks: Bioaccumulation is not expected.
Mobility in soil
No data available
Other adverse effects
Components:
pentane:
Additional ecological informationAvoid release to the environment. Do not empty into drains.
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 3399
Proper shipping name : Organometallic substance, liquid, water-reactive, flammable (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : Division 4.3 - Substances which in contact with water emit flammable gases, Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 494
Packing instruction (passenger aircraft) : Not permitted for transport
Proper shipping name : Organometallic substance, liquid, water-reactive, flammable (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : Division 4.3 - Substances which in contact with water emit flammable gases, Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 494
Packing instruction (passenger aircraft) : Not permitted for transport
IMDG-Code
UN number : UN 3399
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : 4.3 (3)
EmS Code : F-G, S-N
Marine pollutant : yes
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : 4.3 (3)
EmS Code : F-G, S-N
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National regulation GB 6944/12268
UN number : UN 3399
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : 4.3 (3)
National regulation GB 6944/12268
UN number : UN 3399
Proper shipping name : ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE (pentane)
Class : 4.3
Subsidiary risk : 3
Packing group : I
Labels : 4.3 (3)
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
No. / Code Chemical name / Category Threshold quantity
W5.1 Flammable liquids 10 t
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / PC-TWA
Permissible concentration - time weighted average
GBZ 2.1-2007 / PC-STEL AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardization; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; n.o.s. No Observed (Adverse) E fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organizatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - short term exposure limit ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.