Chemical Safety Data Sheet MSDS / SDS

Methyllithium

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Methyllithium
  • CBnumber: CB7234211
  • CAS: 917-54-4
  • EINECS Number: 213-026-4
  • Synonyms: MELI;METHYLLITHIUM

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P231+P232 Handle under inert gas. Protect from moisture.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P370+P378 In case of fire: Use … for extinction.
P422 Store contents under …
P222 Do not allow contact with air.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P402+P404 Store in a dry place. Store in a closed container.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P405 Store locked up.
Hazard statements
H252 Self-heating in large quantities; may catch fire
H303 May be harmfulif swallowed
H315 Causes skin irritation
H318 Causes serious eye damage
H401 Toxic to aquatic life
H225 Highly Flammable liquid and vapour
H260 In contact with water releases flammable gases which may ignite spontaneously
H304 May be fatal if swallowed and enters airways
H314 Causes severe skin burns and eye damage
H335 May cause respiratory irritation
H411 Toxic to aquatic life with long lasting effects
H250 Catches fire spontaneously if exposed to air
H302 Harmful if swallowed
H336 May cause drowsiness or dizziness
H311 Toxic in contact with skin

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Methyllithium
  • Synonyms: MELI;METHYLLITHIUM
  • CAS: 917-54-4
  • EC number: 213-026-4
  • MF: CH3Li
  • MW: 21.98

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Pulmonary failure possible after aspiration of vomit. Call a physician immediately. Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

4.4 Notes to physician

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media
Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
Water Foam

5.2 Special hazards arising from the substance or mixture

Carbon oxides
Lithium oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

3
4
2
W
HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 4 Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas)
REACT 2 Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
SPEC. HAZ. W

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Keep workplace dry. Do not allow product to come into contact with water.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions
Tightly closed. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Never allow product to get in contact with water during storage.
Storage stability
Recommended storage temperature 2 - 8 °C
Test for peroxide formation periodically and before distillation.
Storage class
Storage class (TRGS 510): 4.3: Hazardous materials, which set free flammable gases upon contact with water

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters
['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis']['cumene', '98-82-8', 'TWA', '5 ppm', 'USA. ACGIH Threshold Limit\nValues (TLV)']['', 'Remarks', 'Confirmed animal carcinogen with unknown relevance to\nhumans', None, None]['', '', 'TWA', '50 ppm245\nmg/m3', 'USA. NIOSH Recommended\nExposure Limits']['', '', 'Potential for dermal absorption', None, None]['', '', 'TWA', '50 ppm245\nmg/m3', 'USA. Occupational Exposure\nLimits (OSHA) - Table Z-1\nLimits for Air Contaminants']['', '', 'Skin designation', None, None]['', '', 'PEL', '50 ppm245\nmg/m3', 'California permissible exposure\nlimits for chemical\ncontaminants (Title 8, Article\n107)']
['', '', 'TWA', '50 ppm245\nmg/m3', 'USA. Table Z-1-A Limits for Air\nContaminants (1989 vacated\nvalues)']['', '', 'Skin notation', None, None]

Skin

8.2 Exposure controls

Appropriate engineering controls
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
required
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • a) Physical stateliquid
  • b) ColorColorless to yellow
  • c) OdorNo data available
  • d) Melting point/freezing pointNo data available
  • e) Initial boiling point and boiling range88℃
  • f) Flammability (solid, gas)No data available
  • g) Upper/lower flammability or explosive limits1.7-36% (v/v) Information refers to the main component.)
  • h) Flash point-7 °C
  • i) Autoignition temperatureThe substance or mixture is not classified as pyrophoric.
  • j) Decomposition temperatureNo data available
  • k) pHNo data available
  • l) ViscosityViscosity, kinematic: No data available
    Viscosity, dynamic: No data available
  • m) Water solubilityReacts with water.
  • n) Partition coefficient n-octanol/waterNo data available
  • o) Vapor pressureNo data available
  • p) Density0.86 g/cm3
  • Relative density0.85 g/mL at 20 °C
  • q) Relative vapor density3 (vs air)
  • r) Particle characteristicsNo data available
  • s) Explosive propertiesNot classified as explosive.
  • t) Oxidizing propertiesnone

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Chemical stability

sensitive to moisture

10.2 Possibility of hazardous reactions

No data available

10.3 Conditions to avoid

Warming.
Moisture.

10.4 Incompatible materials

Oxidizing agents, Oxygen, Alcohols, Acids

10.5 Hazardous decomposition products

Peroxides
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture Acute toxicity
Oral: No data available
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Possible carcinogen.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.

11.2 Additional Information

burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components cumene
Acute toxicity
Oral: No data available
Symptoms: gastric pain, Vomiting
Symptoms: mucosal irritations, Cough, Shortness of breath, Headache, Nausea,
Vomiting, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)
Remarks: Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 72 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Red blood cells (erythrocytes)
Result: negative
Method: OECD Test Guideline 474
Species: Rat - male - Bone marrow
Result: Positive results were obtained in some in vivo tests.
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory Tract
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Acute oral toxicity - gastric pain, Vomiting
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath,
Headache, Nausea, Vomiting, Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.
2-Methyltetrahydrofuran Acute toxicity
LD50 Oral - Rat - female - > 300 - 2,000 mg/kg (OECD Test Guideline 420)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - In vitro study
Result: irritating - 15 min (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Corrosive - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
methyllithium Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

SECTION 12: Ecological information

12.1 Toxicity

Mixture
No data available

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available
Components cumene
Toxicity to fish flow-through test LC50 - Cyprinodon variegatus (sheepshead minnow) - 4.7 mg/l - 96 h (US-EPA)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 2.14 mg/l - 48 and other aquatic h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 2.01 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 2,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - 0.35 and other aquatic mg/l - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
2-Methyltetrahydrofuran
Toxicity to fish semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 100 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 139 and other aquatic mg/l - 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 104 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - >= 120 and other aquatic mg/l - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
methyllithium
No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product
Offer surplus and non-recyclable solutions to a licensed disposal company.

SECTION 14: Transport information

14.1 UN number

ADR/RID: 3399
IMDG: 3399
IATA-DGR: 3399

14.2 UN proper shipping name

ADR/RID: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE (methyllithium, 2-Methyltetrahydrofuran, cumene)
IMDG: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE (methyllithium, 2-Methyltetrahydrofuran, cumene)
IATA-DGR: Organometallic substance, liquid, water-reactive, flammable (methyllithium, 2-Methyltetrahydrofuran, cumene)
Passenger Aircraft: Not permitted for transport

14.3 Transport hazard class(es)

ADR/RID: 4.3 (3)
IMDG: 4.3 (3)
IATA-DGR: 4.3 (3)

14.4 Packaging group

ADR/RID: I
IMDG: I
IATA-DGR: I

14.5 Environmental hazards

ADR/RID: yes
IMDG Marine pollutant: yes
IATA-DGR: no

14.6 Special precautions for user

Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.

14.7 Incompatible materials

Oxidizing agents, Oxygen, Alcohols, Acids

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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