11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Possible carcinogen.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components cumene
Acute toxicity
Oral: No data available
Symptoms: gastric pain, Vomiting
Symptoms: mucosal irritations, Cough, Shortness of breath, Headache, Nausea,
Vomiting, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)
Remarks: Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 72 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Red blood cells (erythrocytes)
Result: negative
Method: OECD Test Guideline 474
Species: Rat - male - Bone marrow
Result: Positive results were obtained in some in vivo tests.
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory Tract
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Acute oral toxicity - gastric pain, Vomiting
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath,
Headache, Nausea, Vomiting, Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.
2-Methyltetrahydrofuran Acute toxicity
LD50 Oral - Rat - female - > 300 - 2,000 mg/kg (OECD Test Guideline 420)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - In vitro study
Result: irritating - 15 min (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Corrosive - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
methyllithium Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2