CCT 244747
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- $70 - $1181
- Product name: CCT 244747
- CAS: 1404095-34-6
- MF: C20H24N8O2
- MW: 408.46
- EINECS:
- MDL Number:MFCD25977017
- Synonyms:CCT244747; CCT-244747; CCT 244747;CS-1625;CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;CCT-244747; CCT 244747;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
22 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1216-M005
- Product descriptionCCT244747 ≥95%
- Packaging5mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2857DM
- Product descriptionCID54758482
- Packaging5mg
- Price$326
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging2mg
- Price$142
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging5mg
- Price$236
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging10mg
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging25mg
- Price$709
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging50mg
- Price$1181
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging1mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging2mg
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging5mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging10mg
- Price$620
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging25mg
- Price$1125
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25666
- Product descriptionCCT244747 ≥98%
- Packaging1mg
- Price$70
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25666
- Product descriptionCCT244747 ≥98%
- Packaging5mg
- Price$207
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25666
- Product descriptionCCT244747 ≥98%
- Packaging10mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5919
- Product descriptionCCT244747 >99.0%
- Packaging2mg
- Price$108
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1216-M005 | CCT244747 ≥95% | 5mg | $205 | 2021-12-16 | Buy |
| AK Scientific | 2857DM | CID54758482 | 5mg | $326 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 2mg | $142 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 5mg | $236 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 10mg | $394 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 25mg | $709 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 50mg | $1181 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 1mg | $134 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 2mg | $214 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 5mg | $390 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 10mg | $620 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 25mg | $1125 | 2021-12-16 | Buy |
| Cayman Chemical | 25666 | CCT244747 ≥98% | 1mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 25666 | CCT244747 ≥98% | 5mg | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 25666 | CCT244747 ≥98% | 10mg | $341 | 2024-03-01 | Buy |
| ChemScene | CS-5919 | CCT244747 >99.0% | 2mg | $108 | 2021-12-16 | Buy |
Properties
Boiling point :562.6±50.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.Related product price
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