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ChemicalBook >> CAS DataBase List >> Infigratinib

Infigratinib

Infigratinib price.
  • $50 - $2250
  • Product name: Infigratinib
  • CAS: 872511-34-7
  • MF: C26H31Cl2N7O3
  • MW: 560.48
  • EINECS:
  • MDL Number:MFCD22123241
  • Synonyms:3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;BGJ 398;BGJ-398;BGJ398 (NVP-BGJ398);NVP-BGJ398;3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea NVP-BGJ398;NVP-BGJ398 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, methanesulfonate
Price35 Properties Safety Information Description
35 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • TRC
Package
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1152-M005
  • Product descriptionNVP-BGJ398 ≥95%
  • Packaging5mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1152
  • Product descriptionNVP-BGJ398
  • Packaging100mg
  • Price$555
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045867
  • Product descriptionBGJ-398 95.00%
  • Packaging5MG
  • Price$750.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045867
  • Product descriptionBGJ-398 95.00%
  • Packaging10MG
  • Price$802.73
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045867
  • Product descriptionBGJ-398 95.00%
  • Packaging50MG
  • Price$1328.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3014
  • Product descriptionBGJ398
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60052
  • Product descriptionInfigratinib(BGJ398) ≥98%
  • Packaging20mg
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546258
  • Product descriptionNVP-bGJ398 >98%
  • Packaging10mg
  • Price$181.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546258
  • Product descriptionNVP-bGJ398 >98%
  • Packaging50mg
  • Price$397.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146290
  • Product descriptionNVP-BGJ398(Infigratinib) >98%
  • Packaging100mg
  • Price$542.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146290
  • Product descriptionNVP-BGJ398(Infigratinib) >98%
  • Packaging250mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146290
  • Product descriptionNVP-BGJ398(Infigratinib) >98%
  • Packaging1g
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD46729
  • Product descriptionNVP BGJ 398
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD46729
  • Product descriptionNVP BGJ 398
  • Packaging50mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19157
  • Product descriptionBGJ398 ≥98%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19157
  • Product descriptionBGJ398 ≥98%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1152-M005 NVP-BGJ398 ≥95% 5mg $113 2021-12-16 Buy
AK Scientific SYN1152 NVP-BGJ398 100mg $555 2021-12-16 Buy
American Custom Chemicals Corporation API0045867 BGJ-398 95.00% 5MG $750.2 2021-12-16 Buy
American Custom Chemicals Corporation API0045867 BGJ-398 95.00% 10MG $802.73 2021-12-16 Buy
American Custom Chemicals Corporation API0045867 BGJ-398 95.00% 50MG $1328.25 2021-12-16 Buy
ApexBio Technology A3014 BGJ398 5mg $80 2021-12-16 Buy
Arctom CFN60052 Infigratinib(BGJ398) ≥98% 20mg $208 2021-12-16 Buy
Biorbyt Ltd orb546258 NVP-bGJ398 >98% 10mg $181.9 2021-12-16 Buy
Biorbyt Ltd orb546258 NVP-bGJ398 >98% 50mg $397.8 2021-12-16 Buy
Biorbyt Ltd orb146290 NVP-BGJ398(Infigratinib) >98% 100mg $542.3 2021-12-16 Buy
Biorbyt Ltd orb146290 NVP-BGJ398(Infigratinib) >98% 250mg $986 2021-12-16 Buy
Biorbyt Ltd orb146290 NVP-BGJ398(Infigratinib) >98% 1g $1802 2021-12-16 Buy
Biosynth Carbosynth FD46729 NVP BGJ 398 10mg $80 2021-12-16 Buy
Biosynth Carbosynth FD46729 NVP BGJ 398 50mg $160 2021-12-16 Buy
Cayman Chemical 19157 BGJ398 ≥98% 1mg $62 2024-03-01 Buy
Cayman Chemical 19157 BGJ398 ≥98% 5mg $120 2024-03-01 Buy
Next Last

Properties

Melting point :>211°C (dec.)
Boiling point :747.9±60.0 °C(Predicted)
Density :1.354
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
form :White solid.
pka :11.02±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :QADPYRIHXKWUSV-UHFFFAOYSA-N
SMILES :N(C1C=C(NC2=CC=C(N3CCN(CC)CC3)C=C2)N=CN=1)(C)C(NC1=C(Cl)C(OC)=CC(OC)=C1Cl)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively). It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 μM). BGJ398 has been shown to suppress proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively). In an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3, BGJ398 inhibited tumor growth after oral administration of 10-30 mg/kg.

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Suppliers and manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Infigratinib
$0.00 /1Bag
Infigratinib CAS:872511-34-7
shandong perfect biotechnology co.ltd
Infigratinib (BGJ398)
$0.00 /1g
Infigratinib (BGJ398) CAS:872511-34-7
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Infigratinib (BGJ398)
$2.00 /25KG
Infigratinib (BGJ398) CAS:872511-34-7
PharmOrgSyn Laboratories Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
BOC Sciences
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED