SC 66
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- $15 - $1300
- Product name: SC 66
- CAS: 871361-88-5
- MF: C18H16N2O
- MW: 276.33
- EINECS:
- MDL Number:MFCD05025493
- Synonyms:SC 66;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
68 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10.00mg
- 10
- 10mg
- 25mg
- 50mg
- 50.00mg
- 100mg
- 100.00mg
- 250mg
- 50
- 10mM*1mLinDMSO
- 500mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1G
- 5G
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98%
- Packaging10mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98%
- Packaging50mg
- Price$107
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98
- Packaging25mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98%
- Packaging100mg
- Price$155
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008F8C
- Product descriptionSC66 98%
- Packaging250mg
- Price$252
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65784
- Product description(2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexan-1-one 98%
- Packaging1G
- Price$325
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65784
- Product description(2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexan-1-one 98%
- Packaging5G
- Price$1300
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging1g
- Price$1190
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging250mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging50mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging25mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA225521
- Product description(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+%
- Packaging5mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC 66
- Packaging5mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5575
- Product descriptionSC 66
- Packaging10mg
- Price$94
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008F8C | SC66 98% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA008F8C | SC66 98% | 10mg | $41 | 2026-05-28 | Buy |
| aablocks | AA008F8C | SC66 98% | 50mg | $107 | 2026-05-28 | Buy |
| aablocks | AA008F8C | SC66 98 | 25mg | $98 | 2026-05-28 | Buy |
| aablocks | AA008F8C | SC66 98% | 100mg | $155 | 2026-05-28 | Buy |
| aablocks | AA008F8C | SC66 98% | 250mg | $252 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65784 | (2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexan-1-one 98% | 1G | $325 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65784 | (2E,6E)-2,6-bis(pyridin-4-ylmethylene)cyclohexan-1-one 98% | 5G | $1300 | 2026-05-27 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 1g | $1190 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 250mg | $350 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 50mg | $208 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 25mg | $160 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 10mg | $95 | 2021-12-16 | Buy |
| Ambeed | A225521 | (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone 98+% | 5mg | $51 | 2021-12-16 | Buy |
| ApexBio Technology | B5575 | SC 66 | 5mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | B5575 | SC 66 | 10mg | $94 | 2026-05-06 | Buy |
Properties
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥5mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
InChI :1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
InChIKey :CYVVJSKZRBZHAV-UNZYHPAISA-N
SMILES :O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3
solubility :DMSO: ≥5mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
InChI :1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
InChIKey :CYVVJSKZRBZHAV-UNZYHPAISA-N
SMILES :O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.Related product price
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