4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine synthesis
- Product Name:4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- CAS Number:1196507-57-9
- Molecular formula:C14H8ClF3N2O2S
- Molecular Weight:360.74
![4-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine](/CAS/GIF/1196507-58-0.gif)
1196507-58-0
57 suppliers
$163.00/100mg
98-09-9
344 suppliers
$12.00/25g
1196507-57-9
29 suppliers
$140.00/25mg
Yield:1196507-57-9 85.5%
Reaction Conditions:
with triethylamine in N,N-dimethyl-formamide; for 2 h;Cooling with ice;
Steps:
50.1 First step:
4-chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin 50b
Compound 50a (1.0g, 4.55 mmol), TEA (919 mg, 9.10 mmol) and DMF (10 mL) were added into a reaction flask, and then benzenesulfonyl chloride (800 mg, 4.55 mmol) was slowly added dropwise at an ice bath.
The system was reacted for 2h at that temperature.
After the reaction was completed, water was added.
The system was extracted with EA, dried, concentrated and purified by column chromatography (v/v, DCM/MeOH=100:1-50:1) to obtain compound 50b (1.4g, 3.89 mmol) with a yield of 85.5%. MS m/z (ESI): 361 [M+H]+.
References:
EP3939979,2022,A1 Location in patent:Paragraph 0340-0342
680-15-9
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![1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-1-(phenylsulfonyl)-](/CAS/GIF/1196507-56-8.gif)
1196507-56-8
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1196507-57-9
29 suppliers
$140.00/25mg
![1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-](/CAS/GIF/651744-48-8.gif)
651744-48-8
76 suppliers
$225.00/1g
1196507-57-9
29 suppliers
$140.00/25mg
![4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine](/CAS/GIF/1015609-83-2.gif)
1015609-83-2
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$155.00/50mg
1196507-57-9
29 suppliers
$140.00/25mg
![4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine](/CAS2/GIF/1015610-31-7.gif)
1015610-31-7
88 suppliers
$42.00/250mg
1196507-57-9
29 suppliers
$140.00/25mg