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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate structure

CAS No.: 680-15-9

Chemical Name:: Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Synonyms: METHYL FLUOROSULFONYLDIFLUOROACETATE;METHYL DIFLUORO(FLUOROSULFONYL)ACETATE;2,2-DifL;METHYL 2-(FLUOROSULFONYL)DIFLUOROACETATE;METHYL FLUOROSULPHONYLDIFLUOROACETATE;uorosuL;Methyl difluoro(fluorosulphonyl)acetate;FLUOROSULFONYL(DIFLUORO)ACETIC ACID METHYL ESTER;uoro-2-(fL;RSSYY(Iberdomide)-2

CBNumber:: CB2685744

Molecular Formula:: C3H3F3O4S

Molecular Weight:: 192.11

MDL Number:: MFCD00144316

MOL File:: 680-15-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:44:21

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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Properties

Boiling point	117-118 °C(lit.)
Density	1.509 g/mL at 25 °C(lit.)
refractive index	n20/D 1.351(lit.)
Flash point	118 °F
storage temp.	2-8°C(protect from light)
form	liquid
Specific Gravity	1.52
color	colorless to yellow
BRN	1812896
InChI	InChI=1S/C3H3F3O4S/c1-10-2(7)3(4,5)11(6,8)9/h1H3
InChIKey	GQJCAQADCPTHKN-UHFFFAOYSA-N
SMILES	C(OC)(=O)C(F)(F)S(F)(=O)=O
CAS DataBase Reference	680-15-9(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, methyl ester (680-15-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05

Signal word

Danger

Hazard statements

H226-H314

Precautionary statements

P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

C,Xi

Risk Statements

10-34

Safety Statements

26-36/37/39-45-16

RIDADR

UN 2920 8/PG 2

WGK Germany

10-21

Hazard Note

Irritant

TSCA

HazardClass

3.2

PackingGroup

III

HS Code

29159000

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3
Skin Corr. 1B

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
2		1

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	390755	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97%	680-15-9	5g	$38.3	2026-04-30	Buy
TCI Chemical	F0311	Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	680-15-9	5g	$29	2026-04-30	Buy
TCI Chemical	F0311	Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	680-15-9	25g	$95	2026-04-30	Buy
Usbiological	283263	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Asreported	680-15-9	10g	$305	2026-06-03	Buy
Usbiological	283263	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Asreported	680-15-9	25g	$410	2026-06-03	Buy

Product number	Packaging	Price	Buy
390755	5g	$38.3	Buy
F0311	5g	$29	Buy
F0311	25g	$95	Buy
283263	10g	$305	Buy
283263	25g	$410	Buy

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Chemical Properties, Uses, Production

Synthesis

Synthetic Route of Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Equip a 1000 mL oven-dried three-necked round-bottom flask with a magnetic stir bar, an attached constant-pressure funnel, and a gas outlet. Connect the gas outlet to an empty 500 mL spare trap, which is then connected to the outlet of an inverted glass funnel located directly above a 1000 mL beaker containing 120 g NaOH in 600 mL of water. Add anhydrous methanol (160 g) to the flask. Add tetrafluoroethane-β-sulfonyl lactone (440 g) dropwise to the mixture through a feeding funnel with stirring. Cool the mixture in an ice bath for 3 hours. After the addition is complete, gradually heat the reaction mixture to room temperature. Stir the mixture overnight at room temperature.

After purging with nitrogen for 1 hour to completely remove residual HF from the system, the resulting reaction mixture was washed with water (2 × 400 mL) and brine (2 × 400 mL) to remove residual methanol. The organic phase was collected and dried over anhydrous sodium sulfate. After filtration, the crude product was purified by distillation.

Chemical Properties

clear colorless to yellow liquid

Uses

Efficient reagent for the trifluoromethylation of aryls and difluorocyclopropanation of alkenes.

Uses

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is a useful reagent for the trifluoromethylation of alkyl halides. It is also broadly applicable reagent for perfluoroalkylations for aryl iodides and bromides.

reaction suitability

reaction type: click chemistry

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate synthesis

Synthesis of Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate from Methanol and 2-(Fluorosulfonyl)difluoroacetylchloride

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

3,4-Bis(trifluoromethyl)nitrobenzene Methyl heptafluorobutyrate 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine 1-Bromo-4-(2,2,2-trifluoroethyl)benzene

5-bromo-2-(trifluoromethyl)pyrimidine 1-Nitro-4-(2,2,2-trifluoroethyl)benzene 4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Suppliers

Global Suppliers ( 292)

Supplier	Tel	Email	Country	ProdList	Advantage
Ningbo Fuhe Chemical Co., Ltd.	0574-1806900 18069001216	nbfjj@126.com	China	99	58
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD	571-89189769 15168342188		China	228	62
Yangzhou modier Electronic Materials Co., Ltd	13761402923 19975033992	market@modeltemol.com	China	7841	58
Shanghai F.R. Chemical Technology Co.,Ltd	021-52230662 13795399395	seaman79@126.com	China	295	58
SHANG FLUORO	021-65170832 15601903708	qinba_1@163.com	China	401	60
Shandong Ruihua Fluoride Industry Co., Ltd	530-6233885-001 05306238006	ruihuafluoride@rhfuye.com	China	20	58
Shanghai Jinghui Industrial Co., Ltd.	021-60125035 18019281355	vlchemjh@126.com	China	293	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Ningbo Fuhe Chemical Co., Ltd.	58
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD	62
Yangzhou modier Electronic Materials Co., Ltd	58
Shanghai F.R. Chemical Technology Co.,Ltd	58
SHANG FLUORO	60
Shandong Ruihua Fluoride Industry Co., Ltd	58
Shanghai Jinghui Industrial Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84

View Latest Price from Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-29	Methyl 2-(fluorosulfonyl)difluoroacetate 680-15-9	$890.00		98	5000 Kg	R&D Scientific Inc.
2025-04-04	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
680-15-9
99%
Hebei Chuanghai Biotechnology Co., Ltd

Methyl 2-(fluorosulfonyl)difluoroacetate
680-15-9
$890.00
98
R&D Scientific Inc.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
680-15-9
98%
Henan Aochuang Chemical Co.,Ltd.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Spectrum

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)MS Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)¹HNMR Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)¹³CNMR Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)IR1 Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)Raman

680-15-9 (Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate) Related Search:

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METHYL FLUOROSULPHONYLDIFLUOROACETATE METHYL 2,2-DIFLUORO-2-(FLUOROSULFONYL)ACETATE FLUOROSULFONYL(DIFLUORO)ACETIC ACID METHYL ESTER uoro-2-(fL uorosuL METHYL 2,2-DIFLUORO-2-(FLUOROSULFONYL)-A FLUOROSULFONYL ACETIC ACID METHYL ESTER Methyl fluorosulphonyldifluoroacetate 97% Methylfluorosulphonyldifluoroacetate97% Difluoro(fluorosulfonyl)acetic acid methyl ester Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate,97% Fluorosulfonyldifluoroacetic Acid Methyl Ester Methyl Difluoro(fluorosulfonyl)acetate Difluoro(fluorosulphonyl)acetic acid methyl ester, 1,1-Difluoro-2-methoxy-2-oxoethane-1-sulphonyl fluoride Methyl difluoro(fluorosulphonyl)acetate 97% Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97% Methyl acetate fluorine sulfonyl 2 fluorine 2,2-Difluoro-2-(fluorosulfonyl)-acetic acid methyl ester MethylDifluoro(fluorosulfonyl)acetate> Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, methyl ester Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate ISO 9001：2015 REACH Methyldifluor(fluorsulfonyl)acetat Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9 high quality difluoro-2-(fluorosulfonyl)acetate Methy 2,2-difluoro-2-(fluorosulfonyl)acetate RSSYY(Iberdomide)-2 ethyl 2,2-difluoro-2-(fluorosulfonyl)acetate Methyl2-fluoro-2-(fluorosulfonyl)acetate 2,2-DifL METHYL 2-(FLUOROSULFONYL)DIFLUOROACETATE Methyl difluoro(fluorosulphonyl)acetate METHYL DIFLUORO(FLUOROSULFONYL)ACETATE METHYL FLUOROSULFONYLDIFLUOROACETATE 680-15-9 C3H3F3O4S FSO2CF2CO2CH3 Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Fluorinated Building Blocks Organic Building Blocks Sulfur Compounds Sulfonyl Halides Building Blocks Small molecule Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Synthetic Organic Chemistry Organic Building Blocks Sulfonyl Halides Sulfur Compounds