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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
135133-23-2

(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol synthesis

7synthesis methods
348-57-2 Synthesis
1-Bromo-2,4-difluorobenzene

348-57-2
424 suppliers
$5.00/5g

(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

135133-23-2
22 suppliers
inquiry

-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: magnesium; iodine / tetrahydrofuran / 1.5 h / 20 - 40 °C
2: tetrahydrofuran / 0.75 h / 25 °C
3: N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium hydroxide / N,N-dimethyl-formamide / 4 h / 50 - 70 °C

References:

Second Military Medical University;Zhang Dazhi;Jiang Yuanying;Ni Tingjunhong;Xie Fei;Ding Zichao;Hao Yumeng;Wang Ruina CN110845486, 2020, A

288-88-0 Synthesis
1,2,4-Triazole

288-88-0
797 suppliers
$10.00/5g

2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran

135267-12-8
19 suppliers
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(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

135133-23-2
22 suppliers
inquiry

References
4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

135270-08-5
61 suppliers
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(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

135133-23-2
22 suppliers
inquiry

References
1-Propanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-

148505-34-4
0 suppliers
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(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

135133-23-2
22 suppliers
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References
126918-16-9 Synthesis
1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (2R)-

126918-16-9
11 suppliers
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(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

135133-23-2
22 suppliers
inquiry

References