Tert-Butyl 3-(But-3-Enyl)-3-Hydroxyazetidine-1-Carboxylate synthesis
- Product Name:Tert-Butyl 3-(But-3-Enyl)-3-Hydroxyazetidine-1-Carboxylate
- CAS Number:1446012-46-9
- Molecular formula:C12H21NO3
- Molecular Weight:227.3
398489-26-4
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1446012-46-9
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Yield:1446012-46-9 73%
Reaction Conditions:
Stage #1: 4-but-1-enylmagnesium bromidewith cerium chloride in tetrahydrofuran at 0; for 2 h;Inert atmosphere;
Stage #2: tert-butyl 3-oxoazetidine-1-carboxylate in tetrahydrofuran at -78 - 20;Inert atmosphere;
References:
Kumar, Sarvesh;Thornton, Paul D.;Painter, Thomas O.;Jain, Prashi;Downard, Jared;Douglas, Justin T.;Santini, Conrad [Journal of Organic Chemistry,2013,vol. 78,# 13,p. 6529 - 6539]