Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate synthesis
- Product Name:Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
- CAS Number:148901-69-3
- Molecular formula:C27H26FNO4
- Molecular Weight:447.5
32249-35-7
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148901-69-3
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Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C
2.1: DIBAL-H / toluene / 2 h / 0 °C
3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C
4.2: tetrahydrofuran; hexane / -78 °C
5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C
6.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C
References:
Suzuki;Iwasaki;Fujikawa;Kitahara;Sakashita;Sakoda [Bioorganic and Medicinal Chemistry,2001,vol. 9,# 10,p. 2727 - 2743]
141-97-9
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148901-68-2
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148901-69-3
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$98.00/100mg
121660-11-5
235 suppliers
$6.00/100mg
148901-69-3
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121660-37-5
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148901-69-3
114 suppliers
$98.00/100mg
![(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile](/CAS/GIF/256431-72-8.gif)
256431-72-8
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148901-69-3
114 suppliers
$98.00/100mg