2,4-Dichloroquinazoline synthesis
- Product Name:2,4-Dichloroquinazoline
- CAS Number:607-68-1
- Molecular formula:C8H4Cl2N2
- Molecular Weight:199.04
86-96-4
257 suppliers
$22.00/25g
607-68-1
320 suppliers
$10.00/1g
Yield:607-68-1 99%
Reaction Conditions:
with trichlorophosphate for 2.5 h;Heating / reflux;
Steps:
1.A.1
As depicted above, 2,4(1 H, 3H)- quinazolinedione (2Og, 123.3 mmol) was dissolved in 315ml OfPOCl3 and heated to reflux for 2.5 hours. After cooling to room temperature, the mixture was concentrated in vacuo to remove excess POCl3, poured into saturated aqueous NaHCO3, and extracted with dichloromethane. The product was isolated from the extract 24.3 g (99%)
References:
ANGION BIOMEDICA CORPORATION WO2007/81978, 2007, A2 Location in patent:Page/Page column 67
86-96-4
257 suppliers
$22.00/25g
607-68-1
320 suppliers
$10.00/1g
32315-10-9
432 suppliers
$10.00/1g
1885-29-6
463 suppliers
$5.00/1g
607-68-1
320 suppliers
$10.00/1g
607-69-2
85 suppliers
$37.00/100mg
607-68-1
320 suppliers
$10.00/1g