2,6-Dichloro-5-fluoronicotinic acid synthesis
- Product Name:2,6-Dichloro-5-fluoronicotinic acid
- CAS Number:82671-06-5
- Molecular formula:C6H2Cl2FNO2
- Molecular Weight:209.99
82671-03-2
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82671-06-5
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Yield:82671-06-5 12.91 g (73.2%)
Reaction Conditions:
with trifluoroacetic acid in water;
Steps:
1 1-o,p-Difluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino pyrrolidin-1-yl)-1,8-naphthyridine-3-carboxylic acid hydrochloride salt
Example 1 1-o,p-Difluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino pyrrolidin-1-yl)-1,8-naphthyridine-3-carboxylic acid hydrochloride salt Ethyl 2,6-dichloro-5-fluoronicotinate (20 g, 84 mmol) was dissolved in a mixture of 40 mL of trifluoroacetic acid and 40 mL of 7.5 N HCI. The mixture was heated to reflux for 24 hours. The solution was cooled, and the trifluoroacetic acid was removed by evaporation under reduced pressure. Upon cooling, 100 mL of water was added and a white precipitate formed. The precipitate was filtered, washed with hexane, and dried, yielding 12.91 g (73.2%) of 2,6-dichloro-5-fluoronicotinic acid: mp 153-154°C.
References:
EP302372,1989,A1
148874-68-4
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82671-02-1
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113237-20-0
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82671-06-5
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104866-50-4
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82671-06-5
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