2,6-Dichloro-5-fluoronicotinic acid
- CAS No.
- 82671-06-5
- Chemical Name:
- 2,6-Dichloro-5-fluoronicotinic acid
- Synonyms
- 2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXYLIC ACID;2,6-Dichloro-5-Fluoronicotinic;2,6-DICHLORO-5-FLUORO-3-PYRIDINECARBOXYLIC ACID;RARECHEM AL BO 0975;TIMTEC-BB SBB003450;Fluorine chlorine niacin;Tosufloxacin tosilate Impurity 4;2,6-Dichloro-5-fluoronicotic acid;2,6-Dichloro-5-Fluoronicotinic API;2,6-Dichloro-5-fluoronictonic acid
- CBNumber:
- CB3189052
- Molecular Formula:
- C6H2Cl2FNO2
- Molecular Weight:
- 209.99
- MDL Number:
- MFCD00799517
- MOL File:
- 82671-06-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 152-155 °C (lit.) |
|---|---|
| Boiling point | 247°C (rough estimate) |
| Density | 1.6207 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 1.38±0.32(Predicted) |
| color | White to Yellow to Orange |
| BRN | 4311035 |
| InChI | InChI=1S/C6H2Cl2FNO2/c7-4-2(6(11)12)1-3(9)5(8)10-4/h1H,(H,11,12) |
| InChIKey | LTDGKGCHRNNCAC-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=C(F)C=C1C(O)=O |
| CAS DataBase Reference | 82671-06-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 1 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,6-Dichloro-5-fluoronicotinic acid price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D2610 | 2,6-Dichloro-5-fluoronicotinic Acid >97.0%(T) | 82671-06-5 | 5g | $20 | 2026-04-30 | Buy |
| TCI Chemical | D2610 | 2,6-Dichloro-5-fluoronicotinic Acid >97.0%(T) | 82671-06-5 | 25g | $54 | 2026-04-30 | Buy |
| Usbiological | 230998 | 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid ≥96% (GC) ≥96%(GC) | 82671-06-5 | 1g | $156 | 2026-06-03 | Buy |
| Usbiological | 230998 | 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid ≥96% (GC) ≥96%(GC) | 82671-06-5 | 5g | $159 | 2026-06-03 | Buy |
| Usbiological | 230998 | 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid ≥96% (GC) ≥96%(GC) | 82671-06-5 | 25g | $226 | 2026-06-03 | Buy |
2,6-Dichloro-5-fluoronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
light yellow to beige fine crystalline powder
Uses
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid (2,6-Dichloro-5-fluoro-3-pyridinecarboxylic acid) may be used in the preparation of self assembled monolayer (SAMs) compounds.
Uses
2,6-Dichloro-5-fluoronicotinic Acid is a useful reagent for the modulation of protein-protein interactions to learn about the mechanisms in amyloid assembly.
General Description
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a halogenated heterocyclic compound. Its density has been reported to be 1.6207g/cm3 at 25°C.
Synthesis
82671-03-2
82671-06-5
The general procedure for the synthesis of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid from ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate is as follows: Example 1: 1. ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (20 g, 84 mmol) was dissolved in a mixture of 40 mL of trifluoroacetic acid and 40 mL of 7.5N hydrochloric acid. 2. The mixture was heated to reflux and kept reacting for 24 hours. 3. Upon completion of the reaction, the solution was cooled and the trifluoroacetic acid was removed by evaporation under reduced pressure. 4. After cooling to room temperature, 100 mL of water was added, at which point a white precipitate formed in the solution. 5. The precipitate was collected by filtration, washed with hexane, and dried to give 12.91 g (73.2% yield) of 2,6-dichloro-5-fluoropyridine-3-carboxylic acid, with a melting point of 153-154 °C. The reaction was completed with the addition of 100 mL of water.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 11, p. 2364 - 2369
[2] Patent: EP302372, 1989, A1
[3] Patent: US2014/73631, 2014, A1. Location in patent: Paragraph 0128; 0129
2,6-Dichloro-5-fluoronicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou zhenhe chemical co. LTD | 576-88887792 13386577269 | sales@zhenhechemical.com | China | 115 | 58 |
| Qingdao Dexin Chemical Co., Ltd | 18353358123 | 839877395@qq.com | China | 287 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1459 | 58 |
| Changzhou Huasheng Chemical Technology Co., Ltd | 0519-85861892 13861049519 | 1187729375@qq.com | China | 91 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,6-Dichloro-5-fluoronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-12-29 | 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
|
1kg | 98% | Changzhou waston chemical technology Co.,Ltd | |||
 |
2025-04-04 | 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
- $0.00
- 98%
- Changzhou waston chemical technology Co.,Ltd
-
- 2,6-Dichloro-5-fluoronicotinic acid
82671-06-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
82671-06-5(2,6-Dichloro-5-fluoronicotinic acid)Related Search:
1of4
