2-Acetylbenzimidazole synthesis
- Product Name:2-Acetylbenzimidazole
- CAS Number:18773-95-0
- Molecular formula:C9H8N2O
- Molecular Weight:160.17
51-17-2
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64-19-7
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18773-95-0
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Yield:18773-95-0 100 %
Reaction Conditions:
with acetic anhydride at 20;
Steps:
4.4.3.12. 1-(1H-Benzo[d]imidazole-1-yl)ethan-1-one (3l)
Benzimidazole(0.20 g, 1.7 mmol), Ac2O (3.5 mL, 37.0 mmol) and AcOH (5.0 mL,87.3 mmol) were stirred at RT for 0.5 h. The reaction mixture wasconcentrated under reduced pressure, and then azeotroped with PhMe(x3) to give 1-(1H-benzo[d]imidazole-1-yl)ethan-1-one (270 mg,quant.) as an off-white solid.1H NMR (600 MHz, DMSO-d6) 8.89 (s, 1H), 8.17 (d, J = 7.5 Hz, 1H), 7.76 (d, J = 7.9 Hz, 1H), 7.44-7.35 (m, 2H), 2.75 (s, 3H); 13C NMR(151 MHz, DMSO-d6) 169.1, 144.2, 143.7, 131.2, 125.3, 124.6, 120.0,115.2, 23.7; LCMS m/z 161.0 [M+H]+.
References:
Atkinson, Benjamin N.;Willis, Nicky J.;Zhao, Yuguang;Patel, Chandni;Frew, Sarah;Costelloe, Kathryn;Magno, Lorenza;Svensson, Fredrik;Jones, E. Yvonne;Fish, Paul V. [European Journal of Medicinal Chemistry,2023,vol. 251,art. no. 115132]
51-17-2
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75-36-5
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18773-95-0
44 suppliers
$324.00/5g
51-17-2
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108-24-7
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18773-95-0
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583-39-1
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18773-95-0
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6299-92-9
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546-67-8
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18773-95-0
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52096-23-8
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