2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE synthesis
- Product Name:2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
- CAS Number:72836-33-0
- Molecular formula:C9H8ClN3S2
- Molecular Weight:257.76
104-83-6
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2349-67-9
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![5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 2-[[(4-chlorophenyl)methyl]thio]-7-methyl-](/CAS/20210305/GIF/112589-14-7.gif)
112589-14-7
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72836-33-0
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Yield:72836-33-0 93%
Reaction Conditions:
with sodium hydroxide in ethanol;water;
Steps:
P.4 Synthesis of 2-(4-chlorobenzylthio)-7-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (intermediate)
PREPARATION EXAMPLE 4 Synthesis of 2-(4-chlorobenzylthio)-7-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (intermediate) In 35 ml of water and 70 ml of ethanol, 12.8 g of 2-amino-5-mercapto-1,3,4-thiadiazol and 43 g of sodium hydroxide were added. To this mixture, 14.8 g of 4-chlorobenzyl chloride was added and the mixture was stirred at room temperature for 1 hour. Water was added and the reaction mixture was filtered. The residue was washed with water and an ethanol/n-hexane (1:1) mixture, and was dried under reduced pressure, and thus 23:1 g of 2-amino-5-(4-chlorobenzylthio)-1,3,4-thiadiazole was obtained. m.p. 162°~164° C. Yield 93%.
References:
US4866064,1989,A
104-83-6
385 suppliers
$15.00/50g
2349-67-9
389 suppliers
$6.00/5g
72836-33-0
24 suppliers
$60.00/100mg
622-95-7
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$6.00/1g
2349-67-9
389 suppliers
$6.00/5g
72836-33-0
24 suppliers
$60.00/100mg