2-AMINO-5-BROMO-3-ETHOXYPYRAZINE synthesis
- Product Name:2-AMINO-5-BROMO-3-ETHOXYPYRAZINE
- CAS Number:77112-66-4
- Molecular formula:C6H8BrN3O
- Molecular Weight:218.05
141-52-6
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$10.00/5g
24241-18-7
446 suppliers
$6.00/5g
77112-66-4
56 suppliers
$81.00/1g
Yield:77112-66-4 90%
Reaction Conditions:
in ethanol; for 8 h;Reflux;
Steps:
208.A Part A
A solution of 3,5-dibromopyrazin-2-amine (47.4 g, 190 mmol) and NaOEt (14 g, 206 mmol) in EtOH (500 mL) was heated at reflux for 8 h. The reaction mixture was evaporated to dryness in vacuo and the residue partitioned between H2O (400 mL) and EtOAc (500 mL). The combined organics were dried (MgSO4) and evaporated to dryness in vacuo to afford 5- bromo-3-ethoxypyrazin-2-amine (36.8 g, 90%).
References:
WO2020/263980,2020,A1 Location in patent:Page/Page column 164
24241-18-7
446 suppliers
$6.00/5g
77112-66-4
56 suppliers
$81.00/1g
64-17-5
760 suppliers
$10.00/50g
24241-18-7
446 suppliers
$6.00/5g
77112-66-4
56 suppliers
$81.00/1g