2-Chloro-4-hydroxybenzaldehyde synthesis
- Product Name:2-Chloro-4-hydroxybenzaldehyde
- CAS Number:54439-75-7
- Molecular formula:C8H7ClO2
- Molecular Weight:170.59
56962-11-9
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74-88-4
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54439-75-7
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Yield: 70%
Reaction Conditions:
with potassium carbonate in water;N,N-dimethyl-formamide
Steps:
R.20 -chloro-4-methoxybenzaldehyde
Reference Example 20 -chloro-4-methoxybenzaldehyde To a solution of 2-chloro-4-hydroxybenzaldehyde (2 g, 12.8 mmol) in N,N-dimethylformamide (25 mL) were added potassium carbonate (3.46 g, 25 mmol) and methyl iodide (large excess) and the mixture was stirred at room temperature for 18 h. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.55 g, 70%). 1H-NMR (δ ppm, CDCl3): 3.89 (3H, s), 6.84-6.95 (2H, m), 7.90 (1H, d, J=8.8 Hz), 10.33 (1H, s)
References:
Takeda Chemical Industries, Ltd. EP1223170, 2002, A1
74-88-4
358 suppliers
$15.00/10g
54439-75-7
107 suppliers
$6.00/250mg
123-11-5
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54439-75-7
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43192-31-0
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2186-92-7
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54439-75-7
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108-43-0
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54439-75-7
107 suppliers
$6.00/250mg