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2-Chloro-4-hydroxybenzaldehyde

2-Chloro-4-hydroxybenzaldehyde Structure
2-Chloro-4-hydroxybenzaldehyde structure
CAS No.
56962-11-9
Chemical Name:
2-Chloro-4-hydroxybenzaldehyde
Synonyms
TIMTEC-BB SBB004014;4-Bromo-4-fluoroacetophenone;Benzaldehyde, 2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzaldehyde, 97%,;2-CHLORO-4-HYDROXYBENZALDEHYDE 99% &;2-Chloro-4-hydroxybenzaldehyde ISO 9001：2015 REACH;(1R)-1-(3-bromoisoquinolin-7-yl)-2-phenylethan-1-amine
CBNumber:
CB7401017
Molecular Formula:
C7H5ClO2
Molecular Weight:
156.57
MDL Number:
MFCD00052184
MOL File:
56962-11-9.mol
MSDS File:
SDS
Last updated:2026-05-28 03:01:42
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2-Chloro-4-hydroxybenzaldehyde Properties

Melting point 145-147 °C (lit.)
Boiling point 272.5±20.0 °C(Predicted)
Density 1.404±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in organic solvents.
pka 6.81±0.18(Predicted)
form solid
Appearance Off-white to light yellow Solid
Sensitive Air Sensitive
InChI InChI=1S/C7H5ClO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
InChIKey ZMOMCILMBYEGLD-UHFFFAOYSA-N
SMILES C(=O)C1=CC=C(O)C=C1Cl
CAS DataBase Reference 56962-11-9(CAS DataBase Reference)
NIST Chemistry Reference Benzaldehyde, 2-chloro-4-hydroxy-(56962-11-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HS Code  29124900
Storage Class 11 - Combustible Solids
NFPA 704
1
3 0

2-Chloro-4-hydroxybenzaldehyde price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 346063 2-Chloro-4-hydroxybenzaldehyde 97% 56962-11-9 500mg $44.9 2023-06-20 Buy
TCI Chemical C3873 2-Chloro-4-hydroxybenzaldehyde min. 98.0 % 56962-11-9 1G $91 2026-04-30 Buy
TCI Chemical C3873 2-Chloro-4-hydroxybenzaldehyde min. 98.0 % 56962-11-9 5G $273 2026-04-30 Buy
Usbiological 267416 2-Chloro-4-hydroxybenzaldehyde Asreported 56962-11-9 1g $426 2026-06-03 Buy
Usbiological 267416 2-Chloro-4-hydroxybenzaldehyde Asreported 56962-11-9 2g $616 2026-06-03 Buy
Product number Packaging Price Buy
346063 500mg $44.9 Buy
C3873 1G $91 Buy
C3873 5G $273 Buy
267416 1g $426 Buy
267416 2g $616 Buy

2-Chloro-4-hydroxybenzaldehyde Chemical Properties, Uses, Production

Uses

2-Chloro-4-hydroxybenzaldehyde, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

2-Chloro-4-hydroxybenzaldehyde may be used in chemical synthesis.

General Description

N-Thioamide thiosemicarbazone derivatives of 2-chloro-4-hydroxy-benzaldehyde have been prepared. pK values for acid dissociation of 2-chloro-4-hydroxybenzaldehyde has been evaluated.

Synthesis

3-Chlorophenol

108-43-0

Chloroform

67-66-3

2-Chloro-4-hydroxybenzaldehyde

56962-11-9

The general procedure for the synthesis of 2-chloro-4-hydroxybenzaldehyde from 3-chlorophenol (CAS 108-43-0) (49.2 g, 0.380 mol) and trichloromethane was as follows: first, 3-chlorophenol, calcium hydroxide (122.0 g) and sodium carbonate (139.4 g) were suspended in water (872 mL). Subsequently, trichloromethane (90.6 g, 0.760 mol) was slowly added over 80 min and the reaction mixture was refluxed for 3 h under vigorous stirring. After completion of the reaction, the mixture was cooled in an ice bath. Next, concentrated hydrochloric acid (385 mL) and trichloromethane (300 mL) were added for extraction and the aqueous layer was discarded. The organic layer was dried with anhydrous sodium sulfate (50 g) followed by evaporation of the solvent under vacuum. The residue was purified by silica gel column chromatography (silica gel 63-100 μm, 600 g, eluents sequentially carbon tetrachloride, chloroform, chloroform/ethyl acetate 93:7). Fractions containing the target product were collected, combined, and the solvents were evaporated and co-evaporated with dioxane to yield 2-chloro-4-hydroxybenzaldehyde (9.77 g, 0.062 mol, 16% yield) as a white powder.1H NMR (DMSO-d6) data were as follows: δ 11.06 (s, 1H, aldehydic hydrogens); 10.14 (s, 1H, hydroxyhydrogens); 7.75 ( d, 1H, J = 8.5 Hz, arylhydrogen); 6.92 (d, 1H, J = 2 Hz, arylhydrogen); 6.85 (dd, 1H, J1 = 8.5 Hz, J2 = 2 Hz, arylhydrogen).

References

[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 98
[2] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 45; 47; 48
[3] Patent: EP2289883, 2011, A1. Location in patent: Page/Page column 19
[4] Journal of Chemical & Engineering Data, 1983, vol. 28, # 1, p. 139 - 141
[5] Journal of Organic Chemistry, 1964, vol. 29, p. 2693 - 2698

2-Chloro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

2-Chloro-4-hydroxybenzonitrile 3-Chlorophenol Chloroform Water Hydrochloric acid

Preparation Products

2-Chloro-4-hydroxybenzaldehyde Suppliers

Global Suppliers ( 253)
Supplier Tel Email Country ProdList Advantage
Suzhou Lyran Biopharma And Technology CO.,LTD. 15556287180 15556287180 1184800090@qq.com China 408 58
Huzhou Huanyu Biotechnology Co. , Ltd. 18757211187 18994340517 709951195@qq.com China 94 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
Suzhou Lyran Biopharma And Technology CO.,LTD. 58
Huzhou Huanyu Biotechnology Co. , Ltd. 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66

View Latest Price from 2-Chloro-4-hydroxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-hydroxybenzaldehyde pictures 2026-03-20 2-Chloro-4-hydroxybenzaldehyde
56962-11-9
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Chloro-4-hydroxybenzaldehyde pictures 2021-07-13 2-Chloro-4-hydroxybenzaldehyde
56962-11-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Chloro-4-hydroxybenzaldehyde pictures 2021-07-10 2-Chloro-4-hydroxybenzaldehyde
56962-11-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Chloro-4-hydroxybenzaldehyde Spectrum

2-Chloro-4-hydroxybenzaldehyde(56962-11-9)1HNMR2-Chloro-4-hydroxybenzaldehyde(56962-11-9)Raman2-Chloro-4-hydroxybenzaldehyde(56962-11-9)IR

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Difluorochloromethane 2,3-Dichloro-4-hydroxybenzaldehyde 4-Chloro-2-hydroxybenzaldehyde 3-Chloro-4-hydroxybenzaldehyde 3,5-Dichlorosalicylaldehyde
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Benzaldehyde, 2-chloro-4-hydroxy- TIMTEC-BB SBB004014 2-CHLORO-4-HYDROXYBENZALDEHYDE 99% & 2-Chloro-4-hydroxybenzaldehyde ISO 9001：2015 REACH 2-Chloro-4-hydroxybenzaldehyde, 97%, 4-Bromo-4-fluoroacetophenone (1R)-1-(3-bromoisoquinolin-7-yl)-2-phenylethan-1-amine 56962-11-9 C7H5ClO2 Building Blocks Aldehydes C7 Carbonyl Compounds Organic Building Blocks Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aromatic Aldehydes & Derivatives (substituted) Aromatic Phenylacetic Acids and Derivatives Benzaldehyde Aldehydes C7 Carbonyl Compounds