2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE synthesis
- Product Name:2-CHLORO-N-(4-P-TOLYL-THIAZOL-2-YL)-ACETAMIDE
- CAS Number:6081-87-4
- Molecular formula:C12H11ClN2OS
- Molecular Weight:266.75
2103-91-5
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79-04-9
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$12.00/5g
6081-87-4
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$57.50/250mg
Yield:6081-87-4 81%
Reaction Conditions:
with sodium acetate in acetic acid; for 6 h;Heating;
Steps:
Synthesis of 2-chloro-N-(4-(4-substituted phenyl)thiazol-2-yl) acetamides (5a-f): General procedure
General procedure: 4-(4-substituted phenyl) thiazol-2-amine (0.05 mole) wasdissolved in 25 mL glacial acetic acid containing saturated solution of sodium acetate. To this solution, chloroacetyl chloride (0.06 mole) was added with stirring. Then, the mixture was heated on water bath for 6 h, cool at room temperature, and then poured over crushed ice. The product precipitated out was then filtered, washed with water, dried,and recrystallized from ethanol to afford pure compound in satisfactory yield.
References:
Monga, Vikramdeep;Singh, Hargyan;Singh, Gurpreet [Indian Journal of Heterocyclic Chemistry,2017,vol. 27,# 1,p. 51 - 57]
2010-06-2
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79-04-9
374 suppliers
$12.00/5g
6081-87-4
32 suppliers
$57.50/250mg
122-00-9
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$5.00/25g
6081-87-4
32 suppliers
$57.50/250mg
619-41-0
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$6.00/1g
6081-87-4
32 suppliers
$57.50/250mg