(S)-1-methylpyrrolidin-3-yl (R)-2-cyclopentyl-2-hydroxy-2-phenylacetate synthesis
- Product Name:(S)-1-methylpyrrolidin-3-yl (R)-2-cyclopentyl-2-hydroxy-2-phenylacetate
- CAS Number:207856-85-7
- Molecular formula:C18H25NO3
- Molecular Weight:303.4
64471-47-2
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104641-59-0
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Yield:207856-85-7 89.6%
Reaction Conditions:
Stage #1: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester;(3S)-1-methylpyrrolidin-3-olwith sodium in n-heptane at 110; for 3 h;
Stage #2: with water in n-heptane at 0;
References:
Wu;Wu;Mori;Buchwald;Bodor, Nicholas [Pharmazie,2008,vol. 63,# 3,p. 200 - 209] Location in patent:experimental part
13220-33-2
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64471-45-0
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616866-21-8
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207856-85-7
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611-71-2
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207856-85-7
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894795-19-8
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207856-85-7
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104612-35-3
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207856-85-7
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