ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate synthesis
- Product Name:ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate
- CAS Number:22316-45-6
- Molecular formula:C17H15ClN2O5
- Molecular Weight:362.7644
25781-92-4
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Yield:22316-45-6 91%
Reaction Conditions:
in acetonitrile; for 12 h;Reflux;Large scale;
Steps:
1 Preparation of Compound II
In a 20 L reaction flask,2.5 kg of 2-nitro-5-chlorodiphenylamine was added,16L anhydrous acetonitrile,1.8 kg of malonic acid monoethyl ester chloride,The reaction was heated to reflux for 12 hours.60 vacuum distillation in addition to acetonitrile,Add 8L ethanol stirring dissolved,0 ~ 5 cooling crystallization, pumping filter, dried at 60 yellow crystal weight 3.3kg.Melting point 85-87 ° C, yield 91%.
References:
CN106749052,2017,A Location in patent:Paragraph 0027; 0028
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