3-Bromo-4-fluorophenol synthesis
- Product Name:3-Bromo-4-fluorophenol
- CAS Number:27407-11-0
- Molecular formula:C6H4BrFO
- Molecular Weight:191
286836-26-8
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27407-11-0
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Yield:-
Reaction Conditions:
Stage #1: (3-bromo-4-fluorophenyl) acetatewith sodium hydroxide in ethanol;water; for 20 h;
Stage #2:
Stage #3: with hydrogenchloride in ethanol;water;
Steps:
25.2
Step 2: To the product of Step 1 (2.05 g, 8.8 mmol) in EtOH (20 ml) add 1N NaOH (17.5 ml). Stir 20 h, neutralize with 1N HCl, concentrate, and partition with CH2Cl2 and water. Wash with brine, dry (MgSO4) and concentrate to obtain the phenol as a yellow oil
References:
US2004/220194,2004,A1 Location in patent:Page 19; 20
1007-15-4
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27407-11-0
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937-14-4
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27407-11-0
228 suppliers
$6.00/1g