3-Hydroxy-6-methylpyridine synthesis
- Product Name:3-Hydroxy-6-methylpyridine
- CAS Number:1121-78-4
- Molecular formula:C6H7NO
- Molecular Weight:109.13
55270-47-8
70 suppliers
$65.00/100mg
1121-78-4
284 suppliers
$6.00/5g
Yield:1121-78-4 84%
Reaction Conditions:
with L-Selectride in tetrahydrofuran for 24 h;Reflux;Inert atmosphere;chemoselective reaction;
Steps:
Demethylation of Methoxypyridines; General Procedure:
General procedure: Toa solution of 1 (1.00 mmol) in THF (7.0 mL) was added L-selectride(1 M in THF, 3.0 mL, 3.00 mmol, 3 equiv) under an argonatmosphere. After being refluxed and monitored by TLC, thereaction mixture was quenched with MeOH and evaporated invacuo. The residue was purified by silica gel column chromatographyto give the desired compound 2.
References:
Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo [Synlett,2019,vol. 30,# 8,p. 951 - 954]
3430-13-5
426 suppliers
$5.00/5g
1121-78-4
284 suppliers
$6.00/5g
4808-69-9
87 suppliers
$19.00/100mg
1121-78-4
284 suppliers
$6.00/5g
620-02-0
501 suppliers
$14.14/5gm:
1121-78-4
284 suppliers
$6.00/5g
50-00-0
890 suppliers
$10.00/25g
617-89-0
271 suppliers
$15.00/25mL
1121-78-4
284 suppliers
$6.00/5g