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ChemicalBook CAS DataBase List (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one
327623-36-9

(S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one synthesis

5synthesis methods
30071-93-3 Synthesis
3',5'-Bis(trifluoromethyl)acetophenone

30071-93-3
387 suppliers
$10.00/10g

(S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one

327623-36-9
33 suppliers
inquiry

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C

References:

Brands, Karel M. J.;Payack, Joseph F.;Rosen, Jonathan D.;Nelson, Todd D.;Candelario, Alexander;Huffman, Mark A.;Zhao, Matthew M.;Li, Jing;Craig, Bridgette;Song, Zhiguo J.;Tschaen, David M.;Hansen, Karl;Devine, Paul N.;Pye, Philip J.;Rossen, Kai;Dormer, Peter G.;Reamer, Robert A.;Welch, Christopher J.;Mathre, David J.;Tsou, Nancy N.;McNamara, James M.;Reider, Paul J. [Journal of the American Chemical Society,2003,vol. 125,# 8,p. 2129 - 2135]

287930-73-8 Synthesis
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

287930-73-8
227 suppliers
$6.00/5g

(S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one

327623-36-9
33 suppliers
inquiry

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