4-(dimethyl-1,3-thiazol-2-yl)piperidine synthesis

Yield:1004527-71-2 13%

Reaction Conditions:

with ethanol at 200; for 0.0166667 h;Microwave irradiation;

Steps:

-Bromobutan-2-one (124 mg, 0.8 mmol) and tert-butyl 4- carbamothioylpiperidine-1-carboxylate (200 mg, 0.8 mmol) in ethanol (1 iuL) were heated to 200⁰C for 1 minute under microwave irradiation. The black residue was purified by chromatography (DCM/MeOH/NH₄OH 85/15/0.1) to yield 4,5- dimethyl-2- (piperidin-4-yl) thiazole as a brown solid (32 rag, 13%) : ¹H NMR (400 MHz, DMSCHd₆) δ 1.76-1.88 (m, 2H), 2.08-2.14 (m, 2H), 2.21 (s, 3H), 2.30 (s, 3H), 2.97-3.05 (m, 2H), 3.18- 3.24 (m, IH) , 3.30-3.35 (m, 2H); m/z (APCI pos) 197.1 (100%) [M+H] .

References:

WO2008/11130,2008,A2 Location in patent:Page/Page column 149-150