4-Hydroxycinnamic acid synthesis
- Product Name:4-Hydroxycinnamic acid
- CAS Number:7400-08-0
- Molecular formula:C9H8O3
- Molecular Weight:164.16
141-82-2
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123-08-0
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$5.00/10g
7400-08-0
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Yield:7400-08-0 98%
Reaction Conditions:
with piperidine;pyridine for 1 h;Reflux;Knoevenagel-Doebner-Stobbe Reaction;
Steps:
2.1.1. General Method for Preparation of (E)-cinnamic Acids (16-23)
General procedure: The corresponding benzaldehyde derivative (24-31) (33mmol) and malonic acid (72 mmol) were dissolved in a mixture of 15 mL of pyridine and 0.25 mL of piperidine and heated under reflux until the end of the reaction, monitored by TLC. The reaction medium was cooled, neutralized with HCl (10% aq.), filtered in Buchner funnel, washed with water and dried, providing the appropriate (E)-cinnamic acids(16-23) as described next.
References:
Do Nascimento, Mayara S. S.;Camara, Vitória R. F.;da Costa, Juliana S.;Barbosa, Juliana M. C.;Lins, Alessandra S. M.;Salom?o, Kelly;de Castro, Solange L.;Carvalho, Samir A.;da Silva, Edson F.;Fraga, Carlos A. M. [Medicinal Chemistry,2020,vol. 16,# 6,p. 774 - 783]
106-41-2
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79-10-7
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$20.50/500ml
7400-08-0
453 suppliers
$29.00/10g
113641-76-2
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7400-08-0
453 suppliers
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123-08-0
961 suppliers
$5.00/10g
110-16-7
756 suppliers
$10.00/5g
7400-08-0
453 suppliers
$29.00/10g
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