ChemicalBook CAS DataBase List Malonic acid

Malonic acid synthesis

14synthesis methods

Product Name:Malonic acid
CAS Number:141-82-2
Molecular formula:C3H4O4
Molecular Weight:104.06

Malonic acid is usually produced from chloroacetic acid.
Reaction: The chloroacetic acid is added to the reaction kettle by adding sodium carbonate aqueous solution to generate sodium chloroacetate aqueous solution, and then 30% sodium cyanide solution is slowly added dropwise, and the reaction is carried out at a predetermined temperature to generate sodium cyanoacetate. After the cyanation reaction is completed, add sodium hydroxide for heating and hydrolysis to generate sodium malonate solution, concentrate, then dropwise add sulfuric acid for acidification to generate malonic acid, filter and dry to obtain the product.
Preparation of malonic acid from chloroacetic acid

Preparation of malonic acid from chloroacetic acid

This method often does not produce a pure enough product or the pure product has an extremely low yield. Industrially, malonic acid is also produced by hydrolyzing dimethyl malonate or diethyl malonate. This manufacturing method is able to bring about a higher yield and purity, but the organic synthesis of malonic acid through these processes is extremely costly and environmentally hazardous.

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Yield:141-82-2 97%

Reaction Conditions:

with sodium hydroxide in water;

Steps:

2 Example 2

Example 2 100 g of catalyst were stirred in 500 ml water. To the suspension were subsequently added 90 g of a 10 percent hydroxy propionic acid solution and the temperature was raised to 50° C. while the mixture was being exposed to oxygen. Enough sodium hydroxide was added for the pH-value to remain constant at 8. Exposure to oxygen (30 l/h), temperature and pH-value were maintained for 10.5 h. The product mixture was subsequently analyzed. The conversion of hydroxy propionic acid was 97%, the yield of malonic acid was 95.4%.

References:

US5817870,1998,A