4-acetylbutyric acid synthesis
- Product Name:4-acetylbutyric acid
- CAS Number:3128-06-1
- Molecular formula:C6H10O3
- Molecular Weight:130.14
53293-00-8
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3128-06-1
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$8.00/1g
Yield:3128-06-1 86%
Reaction Conditions:
with [RhCl2(p-cymene)]2;water at 20; for 12 h;
Steps:
General Procedure for Hydration of Terminal Alkynes inPEG-400
General procedure: To a solution of alkyne (1.0 mmol) in PEG-400/H2O(4:1) was added [Ru(p-cymene)Cl2]2 (0.01 mmol), and themixture stirred at room temperature. Upon completion of thereaction (monitoring by TLC), the reaction mixture was dilutedwith Et2O (10 mL), stirred for 10 min, and allowed to stand in anice-salt bath to solidify the PEG-400. The organic layer wasdecanted, dried over anhydrous Na2SO4, filtered, and concentratedunder reduced pressure. The residue obtained was purifiedby silica gel flash column chromatography (ethyl acetate-petroleum ether) to give the pure product.
References:
Mainkar, Prathama S.;Chippala, Venkataraju;Chegondi, Rambabu;Chandrasekhar, Srivari [Synlett,2016,vol. 27,# 13,art. no. ST-2016-D0217-L,p. 1969 - 1972] Location in patent:supporting information
1577-22-6
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3128-06-1
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1193-18-6
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3128-06-1
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504-02-9
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3128-06-1
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57-48-7
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67-47-0
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3128-06-1
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